DCEG investigators have a major interest in identifying genetic modifiers of risk for osteosarcoma. This work builds upon initial observations by Dr. Sharon Savage in the Bone Disease and Injury Study of Osteosarcoma. Analyses of single nucleotide polymorphisms in osteosarcoma cases and controls found associations between several biologically plausible genes and osteosarcoma risk. Our registry studies of osteosarcoma have further refined the epidemiology of this primary bone cancer of adolescents and young adults. Additionally, through an international collaborative effort, we showed strong associations between height at diagnosis and birth weight with osteosarcoma.
In collaboration with the Children’s Oncology Group and multiple international institutions, we are conducting genomic studies to expand our understanding of the genetic contribution to osteosarcoma etiology and outcomes.
A case-control study of osteosarcoma initiated in 1995 between NCI and the Harvard Dental School
A study of osteosarcoma risk factors in collaboration wtih the U.S. Children's Oncology Group
Analyses of cancer registry data to characterize the descriptive epidemiology of osteosarcoma