A hospital based case-control study was conducted from 1999 to 2003 to evaluate kidney cancer risks in relation to occupational and other environmental and lifestyle exposures in 6-centers across Eastern Europe (Moscow, Russia; Brno, Prague, and Central Moravia, Czech Republic; Lodz, Poland; Bucharest, Romania). Over a two year period, DCEG investigators interviewed and collected blood from 1,100 cancer cases and 1,500 controls, and collected tumor tissues from the cases. The study focused on evaluating several occupational exposures for which data are inconclusive. DNA from blood will be used for gene-environment interaction studies. DNA from tumor tissue will be used to examine carcinogen fingerprints using mutational spectrum and methylation analyses of the VHL gene, chromosomal arrays, and immunohistochemistry.
The VHL-HIF (von Hippel Lindau-Hypoxia Inducible Factor) pathway has been implicated in the etiology of cancer, especially renal cell carcinoma. To date, the role of common genetic variants in genes in the VHL-HIF pathway has not been investigated in the susceptibility of kidney cancer in a large population. The objective of this project is to investigate whether single nucleotide polymorphisms (SNPs) or haplotypes in genes of the VHL-HIF pathway are associated with the susceptibility to kidney cancer in the general population.
For more information, contact Lee Moore.