The Epidemiology of Burkitt Lymphoma in East-African Children and Minors (EMBLEM) study is a large, multidisciplinary epidemiological effort designed to evaluate environmental and host factors associated with childhood Burkitt lymphoma (BL) in sub-Saharan Africa. The study is expected to enroll 1,500 BL cases and 3,000 population controls from six rural sites in the East African regions northern Uganda, northeastern Tanzania, and western Kenya. The primary objectives of EMBLEM are to characterize and quantify the association between BL and: a) malaria, based on carriage of malaria-resistance genes; b) carcinogenic Epstein-Barr virus variants; and c) non-malaria-resistance related germline and somatic genetic polymorphisms. In addition to collecting a unique data and sample resource for study of the interplay between infectious agents, genetics, and behavioral/lifestyle factors in the pathogenesis of childhood BL, EMBLEM provides a new model for direct and immediate improvements in BL communication, diagnosis, and treatment of BL in Africa.
For more information, contact Sam Mbulaiteye.