The Epidemiology of Burkitt Lymphoma in East-African Children and Minors (EMBLEM) study is a large, multidisciplinary epidemiological effort designed to evaluate environmental and host factors associated with childhood Burkitt lymphoma (BL) in sub-Saharan Africa. The study is expected to enroll 1,500 BL cases and 3,000 population controls from four sites in East Africa. While evaluation of joint effects will require completion of accrual expected to require a total of five years, important interim analyses are envisioned to evaluate well-powered main effects within the next couple of years. Examples of genetic and environmental main effects that will be evaluated include 1) specific candidate gene polymorphisms associated with malaria resistance and postulated to influence BL risk, 2) common EBV variants defined within our study population, and 3) other common infectious/parasitic conditions postulated to be linked to BL development. Ultimately, the EMBLEM study should provide important new clues to the determinants of BL risk and the interplay between infectious agents, genetics, and behavioral/lifestyle factors in the pathogenesis of childhood BL.
For more information, contact Sam Mbulaiteye.