A case-control study was conducted in Taiwan between 1991-1994 among approximately 1,000 individuals to examine the role of viral, environmental, and genetic factors associated with the development of nasopharyngeal carcinoma (NPC). Factors investigated included Epstein-Barr virus, diet, smoking, occupation, HLA, and other polymorphisms. Histologically confirmed incident cases of nasopharyngeal cancer and two controls groups (hospital and community) were recruited. Participants completed an in-depth, in-person risk factor questionnaire that obtained information on adult and childhood exposures. Mothers of cases and controls were also interviewed to obtain information on dietary patterns in early life. Blood, urine, and toe-nail specimens were collected from all participants to allow for molecular assessment of various environmental and genetic factors of interest, and biopsy tissue was obtained from all cases and hospital controls.
For more information, contact Allan Hildesheim.