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Benign Reproductive Tissue Evaluation Study

The Benign Reproductive Tissue Evaluation (BRTE) Study was initiated by DCEG in collaboration with Magee-Womens Hospital of the University of Pittsburgh to study the association of risk factors with molecular changes in the ovaries and endometrium. In this ongoing study, women undergoing hysterectomy and oophorectomy for benign reasons are enrolled. An extensive risk factor questionnaire is administered and blood and urine samples are collected before surgery. Normal endometrial and ovarian tissues are collected during surgery. In the current phase of the study, investigators are also collecting normal ovarian surface epithelial cells intraoperatively using a Tao brush. More than 160 women have been enrolled in the study so far. Several analyses are currently ongoing, including methylation profiling and telomere length measurement of endometrial tissues as well as RNA sequencing and methylation profiling of ovarian surface epithelial cells. Molecular profiles will be related to important risk factors for endometrial and ovarian cancers.

For more information, contact Nicolas Wentzensen.

Hormonal and Reproductive Epidemiology Branch - Research Areas