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Discovering the causes of cancer and the means of prevention

Serum Sex Steroids and Their Metabolites in Relation to Ovarian and Endometrial Cancer in WHIOS

In collaboration with investigators from the Women’s Health Initiative, investigators in DCEG are conducting a nested case-control study of endometrial and ovarian cancers to assess the roles of estrogens, estrogen metabolites, and androgens in the etiologies of these cancers. Cases and shared controls have been drawn from the Women’s Health Initiative Observational Study (WHIOS) cohort. This effort benefits from unique WHIOS resources, including large numbers of cancer cases, prospectively collected serum and baseline data on important cancer risk factors. Study will evaluate circulating levels of 15 estrogens and estrogen metabolites and 11 androgens and androgen metabolites as measured by LC/MS-MS to cancer risk based on approximately 440 ovarian and 650 endometrial cancer cases.

For more information, contact Britton Trabert, Louise Brinton, and Nicolas Wentzensen

Hormonal and Reproductive Epidemiology Branch - Research Areas