The ongoing Ghana study is designed to assess the burden of prostate cancer in Ghana in order to evaluate how the impact of prostate cancer among West Africans compares to that among African-Americans, whose reported incidence rates are among the highest in the world. West Africans and African-Americans share genetic ancestry but have very different lifestyles and environmental exposures. This study has two components: a clinical survey to estimate the incidence of clinical prostate cancer in Accra and a population screening survey to estimate the prevalence of prostate cancer in the male Accra population. The clinical component of the study includes the collection of clinical and pathological data for the more than 500 prostate cancer cases diagnosed over the last five years. The population component of the study seeks to screen 1,000 healthy men, using serum prostate specific antigen (PSA) testing and digital rectal examination, followed by biopsy confirmation as required. Interviews will be conducted to elicit information on demographics, diet, smoking, alcohol consumption, body size, medical history, health care utilization, and urinary symptoms. The collected blood samples will be used for PSA testing and for measurements of genetic, hormonal, and nutritional markers.
For more information, contact Michael Cook.