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Ghana Prostate Study

The Ghana Prostate Study is designed to assess the burden, risk factor profiles and biomarkers of prostate cancer in Ghanaian men. In the United States, incidence rates of prostate cancer in African-Americans are 1.6-fold higher than those observed in European Americans, yet the causes of this difference remain unknown. Since West Africa is the principal ancestral origin of a substantial proportion of African-American men, one may hypothesize that genetic susceptibility loci that vary in allele frequency by ancestral population could account for part of the observed differences in prostate cancer rates within the US. In addition, little is known about the prostate cancer risk factors in African men.

The Ghana Prostate Study has two components: a clinical component to recruit prostate cancer cases in Accra, the capital of Ghana, and a population screening survey component to estimate the prevalence of prostate cancer in the male Accra population. The clinical component of the study includes the collection of clinical and pathological data for 677 prostate cancer cases. The population component of the study includes 1,000 healthy men who underwent screening using serum prostate specific antigen (PSA) testing and digital rectal examination, followed by biopsy confirmation as required. Interviews elicited information on demographics, diet, smoking, alcohol consumption, body size, medical history, health care utilization, and urinary symptoms. Blood samples are being used for PSA testing and for measurements of genetic, hormonal, and nutritional markers.

Selected publications from the study include:

Cook MB, Wang Z,Yeboah ED, et al. A genome-wide association study of prostate cancer in West African men. Hum Genet 2014 May;133:509-521

Chung CC, Hsing AW, Edward Yeboah, et al. A comprehensive resequence-analysis of 250 kb region of 8q24.21 in men of African ancestry. Prostate 2014 May;74:579-589.

Wang Z, Zhu B, Zhang M, et al. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet 2014 Jul 15. pii: ddu363. [Epub ahead of print]

Al Olama AA, Kote-Jarai Z, Berndt SI, et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet 2014 Oct;46:1103-1109. doi: 10.1038/ng.3094. [Epub ahead of print]

Hsing AW, Yeboah E, Biritwum R, et al. High prevalence of screen detected prostate cancer in west africans: implications for racial disparity of prostate cancer. J Urol 2014 Sep;192:730-736. doi: 10.1016/j.juro.2014.04.017.

Chokkalingam AP, Yeboah ED, Demarzo A, et al. Prevalence of BPH and lower urinary tract symptoms in West Africans. Prostate Cancer Prostatic Dis. 2012 Jun;15:170-176. doi: 10.1038/pcan.2011.43.

For more information, contact Michael Cook.

Hormonal and Reproductive Epidemiology Branch - Research Areas