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Upper Gastrointestinal Cancer Genetic Studies in Shanxi Province, China

The Upper Gastrointestinal Cancer Genetic Studies in Shanxi Province, China, were started in 1995 to look for major susceptibility genes for upper gastrointestinal (UGI) cancers and to identify the genetic changes associated with their development. This project was initiated to study esophageal squamous cell carcinomas, but also includes other UGI cancers (gastric cardia cancer and gastric non-cardia cancer). The project goals include: 

  • Studies of somatic genetic alterations in tumors; 
  • Evaluation of somatic molecular markers in pre-malignant tissues in our search for early detection markers; and 
  • Examination of cancer-associated germline genetic variants to identify major risk and moderate risk susceptibility genes to enable development of risk stratification strategies and a better understanding of the biology of these UGI cancers.

For more information, contact Philip Taylor.

Genetic Epidemiology Branch - Research Areas