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Familial Blood and Lymph Node Cancers Study

Genetic Epidemiology Branch (GEB) investigators have been studying the causes of familial blood and lymph node cancers for over 30 years. Ongoing advances in genetics, anticipated applications of advanced technologies, and our data from the families we have studied have led us to expand and intensify our research efforts in this area. We are actively recruiting new families to participate in our research. The primary focus of our protocol is on five major areas that together make up a group of diseases called "lymphoproliferative disorders":

  • Chronic lymphocytic leukemia (CLL)
  • Hodgkin lymphoma (HL)
  • Non-Hodgkin lymphoma (NHL)
  • Waldenström's macroglobulinemia (WM)
  • Multiple myeloma (MM)

With certain exceptions, we are studying families who have at least two living members who both have the same lymphoproliferative disorder (for example, a family with two members who both have CLL). The specific goals and methods vary somewhat according to the specific disease under study. The studies may include: completion of detailed medical history questionnaires, review of pertinent medical records and pathology materials, clinical evaluation, and donation of blood and/or cheek cell samples for research. The clinical evaluation includes a medical history and physical examination and may also entail disease-related laboratory or imaging studies. In certain cases, patients may be invited to visit the NIH Warren G. Magnuson Clinical Center in Bethesda, Maryland, for evaluation. Otherwise, study components can often be completed in or near the patient's home community.

Contact Information 

To refer new families to us, or to discuss one of our studies in greater detail, family members or health professionals can contact Stephanie Steinbart, our Cancer Genetics Referral Nurse, at 1-800-518-8474, 301-881-1460, or email her at stephaniesteinbart@westat.com.

Resources

Familial Chronic Lymphocytic Leukemia Study Information - Familial Leukemia
Waldenström's Macroglobulinemia Study Information

Links

NIH Clinical Studies for Blood and Lymph Node Cancers Protocol #02-C-0210
PDQ for Blood and Lymph Node Cancers Protocol #02-C-0210
Cancer.gov - Leukemia
Cancer.gov - Hodgkin Lymphoma
Cancer.gov - Non-Hodgkin Lymphoma
The American Cancer Society
Leukemia and Lymphoma Society
Association of Cancer Online Resources
International Waldenstrôm's Macroglobulinemia Foundation
Research Fund for Waldenstrôm's
People Living with Cancer