This population-based natural history study of human papillomavirus (HPV) and cervical neoplasia was launched with Costa Rican colleagues in 1993 in the province of Guanacaste. Over 10,000 randomly selected women were followed longitudinally for seven years. The project yielded many insights into HPV natural history and the performance of then-novel HPV and cytologic screening techniques. Residual specimens are being used to study remaining natural history questions.
For more information, contact Mark Schiffman.