This study is designed to interrogate the relationship between sequence changes in the HPV viral genome and carcinogenicity. The simple question is “Why is HPV 16 so uniquely carcinogenic?” High-throughput next-generation sequencing methods are being used to study HPV 16 variant sub-lineages among women with cancer and CIN 3 in comparison to women with benign HPV infections.
For more information, contact Mark Schiffman and Michael Cullen.