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Discovering the causes of cancer and the means of prevention

Human Papillomavirus (HPV) Viral Genomics

This study is designed to interrogate the relationship between sequence changes in the HPV viral genome and carcinogenicity. The simple question is “Why is HPV 16 so uniquely carcinogenic?” High-throughput, next-generation sequencing methods are being used to study HPV 16 variant sub-lineages among women with cancer and cervical intraepithelial neoplasia 3 (CIN 3) in comparison to women with benign HPV infections. A global, high-risk HPV sequencing method has now been developed, and we are comparing HPV 16-related types to HPV 16.

For more information, contact Mark Schiffman.

Clinical Genetics Branch - Research Areas