This cohort study is evaluating the environmental and genetic risk factors for esophageal squamous cell carcinoma (ESCC) in Golestan Province, Iran. The study is led by the Digestive Disease Research Center of Tehran University of Medical Sciences in collaboration with DCEG and the International Agency for Research on Cancer (IARC) in Lyon. From 2004 – 2008, the study recruited approximately 50,000 adults. Baseline assessments included a lifestyle questionnaire, a semi-quantitative food frequency questionnaire, and collection of blood, hair, nails and urine. Measurements included height, weight, waist and hip circumference, body size at different ages, and physical activity. Annual follow-up is ongoing.
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