Leukemia is a type of blood cancer that begins in the bone marrow. Leukemia is characterized by large numbers of abnormal blood cells that are produced and then enter the bloodstream. DCEG researchers are investigating novel, molecular biomarkers for leukemia, as well as clarifying relationships of established risk factors. Selected studies include:
A binational, multidisciplinary study of Chinese benzene-exposed workers and unexposed workers from more than 700 factories in 12 cities
Studies to investigate occupational formaldehyde exposure and cancer risk, including an industrial cohort study of over 25,000 workers, a case-control study of workers in the funeral industry, and a cross-sectional study to quantify leukemia-specific chromosome changes associated with formaldehyde exposure
Collaborative epidemiological studies of thyroid diseases and leukemia among young persons and clean-up workers associated with the accident at the Chernobyl nuclear power plant in Ukraine
A population-based case-control study of childhood leukemia in the San Francisco Bay area and the agricultural Central Valley
Studies using pooled data from large case-control studies of childhood leukemia conducted in four countries: Canada, Germany, the United Kingdom, and the United States
A study of families with multiple cases of chronic lymphocytic leukemia, the most common leukemia in adults in the Western Hemisphere and one of a group called "lymphoproliferative disorders"
A study of a group of familial blood and lymph node cancers (also called "lymphoproliferative disorders"), including: chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, Waldenström's macroglobulinemia, and multiple myeloma
A study of inherited bone marrow failure syndromes (IBMFS), a group of rare genetic blood disorders that include Fanconi Anemia, Dyskeratosis Congenita, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia, and Thrombocytopenia Absent Radii.
A clinical study and multi-institutional collaboration for research on Li-Fraumeni Syndrome
A study developed at NCI to improve our understanding of the relationship between diet and a wide range of malignancies