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Discovering the causes of cancer and the means of prevention

Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study was a cancer prevention trial conducted by NCI and the National Institute for Health and Welfare of Finland from 1985 to 1993. The purpose of the study was to determine whether certain vitamin supplements would prevent lung cancer and other cancers in a group of 29,133 male smokers in Finland. Participants have been followed since 1993 to evaluate the long-term effects of the vitamins on cancer incidence, and on overall and cause-specific mortality. 

The ATBC Study has been an important cohort study and resource for cancer etiologic research in DCEG, NCI, and elsewhere for over a decade, based on the risk factor data, serum, and genomic DNA samples that were collected, and ongoing linkage with the Finnish Cancer and Mortality Registries.  DCEG currently is conducting biomarker, molecular, and genetic studies. Another important dimension of the ATBC Study is its participation in large cancer and cohort consortia in collaboration with extramural researchers.

For more information, contact Demetrius Albanes.

Metabolic Epidemiology Branch - Research Areas