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MultAssoc

MultiAssoc is a MATLAB software package for test of association of a disease with a group of SNPs after accounting for their interaction with another group of SNPs or environmental exposures. In addition to implementing two standard logistic regression based tests, the package implements a novel method, called TukAssoc , that uses the Tukey’s 1 d.f. model for interaction between two groups of covariates.

Download Software: 

  • Download the MultAssoc.zip file and unpack it in an appropriate directoty. 
  • In MATLAB, use the (file--> set path) menu to add the directory to the search path in which the files have been placed. The main function the user needs to call is 'multilocus_test'. 
  • Please read input_output.txt file for instruction about the input and output arguments.

Reference:

Chatterjee N., Kalaylioglu Z., Moslehi R., Peters U., Wacholder S. (2006). Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. American Journal of Human Genetics, Vol. 79, 1002-16.

Support:

Questions? Contact: Nilanjan Chatterjee