The Agricultural Health Study is a prospective cohort of about 90,000 commercial pesticide applicators, farmers and farmers' spouses from Iowa and North Carolina. It is a collaborative project involving the National Cancer Institute, the National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency and the National Institute for Occupational Safety and Health.
Since it began in 1993, the study has included three cohort-wide interviews to obtain information on agricultural practices and pesticide use, other occupational exposures, lifestyle factors diseases and medication use. Cancer incidence has been ascertained via linkage to population-based cancer registries in the study states, and mortality through linkage to state mortality registries and the National Death Index. Mouth rinse samples, including buccal cell DNA were collected from 39% of the cohort. In addition, there have been a number of targeted sub-studies, focused on specific scientific questions. These studies include information on pesticide exposure monitoring from a sample of farms and the collection of a variety of biologic tissues from selected samples of participants. Collaborative ventures with extramural investigators are encouraged.