Development of an International Prostate Cancer Risk Tool Integrating Data from Multiple Heterogeneous Cohorts - Dr. Donna Ankerst
DCEG Events
March 21, 2019 | 10:30 AM – 11:30 AM
NCI Shady Grove Rockville, MD
BB Seminar
Speaker
Donna Ankerst, Ph.D.
Dept. of Mathematics, Technical University of Munich
Abstract
The Prostate Biopsy Collaborative Group (PBCG) collects prostate cancer risk factors and biopsy outcomes from multiple international centers with the objective to improve biopsy decision-making. The authors recently developed a global risk prediction model for outcomes on prostate biopsy, and posted it online for worldwide use. Construction of the logistic regression model required integrating data from 8492 biopsies from ten diverse centers across North America and Europe. It involved decisions on choice of model, for example, whether to include random effects, as well as the detection of outlying cohorts. The authors outline here the data visualization and cohort-permutation internal validation strategy used to develop the PBCG model, the utility of which makes it applicable for future multi-cohort modeling applications.
**The mission of the Biostatistics Branch (BB) is to be an outstanding biostatistics unit that can contribute to the understanding of cancer etiology and to improve public health by with the development and application of quantitative methods. The BB Investigators develop statistical methods and data resources to strengthen observational studies, intervention trials, and laboratory investigations of cancer.**
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