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baby with DICER1 variant and physicianCancer Risk in Non-Proband DICER1-Variant Carriers
A new report establishes the first quantitative, site-specific risk for benign and malignant tumors in over one hundred non-proband individuals with a germline DICER1 pathogenic variant.

Male patient consults doctor about testicular germ cell tumorCHEK2 Identified as Intermediate-risk Driver of Testicular Germ Cell Tumor (TGCT) Susceptibility
CHEK2 germline pathogenic variants are associated with a four-to-six times elevated risk for TGCT, and an average age at presentation six years earlier than carriers of wild-type alleles.

blankInterferon Lambda Experts Meet at NIH to Discuss Disease Impact and Translational Potential
In October 2018, researchers at the National Cancer Institute hosted a meeting entitled, “IFN Lambda: Disease Impact and Translational Potential,” on the campus of the National Institutes of Health in Bethesda, Maryland.

blankDrug Overdose Deaths a National Problem, not Limited to Poor, Rural Counties
Researchers in the NCI Division of Cancer Epidemiology and Genetics and collaborators at the National Institutes of Health evaluated U.S. death rates from drug poisoning across the country to determine whether increases in these deaths are limited to poor, rural, white communities in regions with high unemployment.

Jonas Almeida Named Chief Data Scientist of DCEG
Dr. Almeida is internationally recognized for his work on integrative biomedical applications that combine systems biology, computational statistics, and software engineering.

HPV Screening History Important for Management of New, Abnormal Results
Women undergoing routine cervical cancer screening who test positive for HPV or related cytologic abnormalities, after a history of negative cotests, have very low risk of precancer or cancer from that new abnormality. The findings confirm and reflect the natural history of HPV and cervical carcinogenesis.

Several bottles of chemotherapy medicinesStudy Finds Elevated Risk of Rare Blood Cancers after Chemotherapy
New study shows that patients experience increased risk of certain rare blood cancers after chemotherapy for most solid tumors.

Joseph Fraumeni, Helga Ogmundsdottir, Mary McMasterÖgmundsdóttir Delivers Seminar on Genetic Predisposition to Waldenström's Macroglobulinemia
In December 2018, Prof. Helga Ögmundsdóttir from the University of Iceland presented a seminar, “Genetic predisposition to Waldenström's macroglæobulinemia- lessons from family studies”. 

Pragati Advani and Sally Peprah2018 Sallie Rosen Kaplan Fellowship Recipients and Selections for the Diversity Career Development Program
Four DCEG fellows awarded Sallie Rosen Kaplan (SRK) Postdoctoral Fellowships for Women Scientists for 2018. Two DCEG fellows selected for 2018 Diversity Career Development Program.

smokestacks emitting smoke against a blue skyAssociation between Benzene Exposure and Leukemia Risk Refined
In a follow-up to a long-term study of Chinese workers exposed to benzene, DCEG researchers observed increased risks for the combined grouping of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with increasing cumulative exposure for certain windows and ages of exposure.

black and yellow radiation signPediatric Considerations Before, During, and After Radiological/Nuclear Emergencies
A new report, “Pediatric Considerations Before, During, and After Radiological/Nuclear Emergencies,” published in the November 2018 issue of Pediatrics, summarizes appropriate management of the pediatric population in the event of a radiologic disaster.

Female doctor points to computer screen with MRI brain scan, shows to male nurseTrends in Pediatric Central Nervous System Tumor Incidence in U.S., 1998-2013
Overall pediatric brain cancer rates have remained stable; however, there were changes in the incidence rates of several sub-types: modest increases in glioma and pilocytic astrocytoma and decreases in embryonal cancer.

Sandy Dawsey receives award from Stephen ChanockStaff Recognized at Fall 2018 Town Hall
DCEG Director Stephen Chanock highlighted new developments across the Division, recognized outstanding contributions from fellows and investigators.

NCI Director's Award Ceremony, Many DCEG Staff Recognized
On November 8, 2018, many deserving DCEG staff were recognized at the NCI Director’s Award ceremony.

No Safe Level of Smoking: Mortality Risks Described for Occasional Smokers and Smokers Who Cut Back
DCEG investigators examined how non-daily smoking and changes in the number of cigarettes smoked per day affect mortality: Any amount of smoking increases mortality risk.

Sauve Award Prix Jules Brodeur
Jean-Francois Sauve, Ph.D., M.Sc., a postdoctoral fellow in the Occupational and Environmental Epidemiology Branch (OEEB) received the 2018 Prix Jules Brodeur.

Simon recognized for service to HHS Special Exposure Cohort Administrative Review Panels
Dr. Steven Simon was recognized by HHS for his service on Special Exposure Cohort Administrative Review Panels for the Energy Employees Occupational Illness Compensation Program Act of 2000.

blankRegina Ziegler Retires from DCEG
In October 2018, Regina G. Ziegler retired after nearly 40 years of service. Dr. Ziegler is widely recognized for her expertise in nutritional epidemiology, incorporating circulating biomarkers into epidemiologic studies, and facilitating the development of assays needed by cancer epidemiologists.

blank Understanding the Etiology of Gynecologic Cancers: Profile of Tenure-Track Investigator Britton Trabert
Tenure-track investigator Britton Trabert, Ph.D., M.S., studies the epidemiology of ovarian cancer and the hormonal etiology of gynecologic cancers.

blank Metabolomics: The Growing Potential of an Emerging Field
DCEG scientists have been evaluating the performance of metabolomics assays and applying them to studies of cancer etiology.

blank Redesign of NCI Risk Assessment Tools for Breast and Colorectal Cancers
DCEG’s communications team and scientific staff upgraded the user interface of NCI risk assessment tools that allow health professionals to quickly assess patients’ breast or colorectal cancer risk.

blank Sandler Delivers 2018 Visiting Scholar Seminar on Prospective Studies of Environment and Health
Dr. Dale Sandler, Chief of the Epidemiology Branch of the National Institute of Environmental Health Sciences was a DCEG Visiting Scholar. Her seminar, “Prospective Studies of Environment and Health” focused on the design, execution, and results of the Gulf Long-term Follow-up Study, a massive undertaking she coordinated to investigate health effects among workers involved in the clean-up of the 2010 Deepwater Horizon disaster.

Gretchen Gierach Appointed Deputy Chief ITEB
Dr. Gretchen Gierach was appointed Deputy Chief of the Integrative Tumor Epidemiology Branch.

blank Scientific Highlights July - October 2018
Scientific papers published by DCEG scientists July through October, 2018. Cancer Topics: All-Cause Mortality, Bladder, Breast, Esophagus, Ewing Sarcoma, Kidney, Leukemia, Lung, Multiple Myeloma, Physical Activity, Prostate, Radiation, Stomach

blank Occupational Exposure to Low-dose Ionizing Radiation Increases Risk of Cataract
Investigators in the Radiation Epidemiology Branch have identified a significant exposure-response between low-dose cumulative occupational radiation exposure to the eye lens and risk of cataracts.

blank For HPV-Positive Women, Test Can Guide Cervical Cancer Screening Follow-Up
A new test can help to improve the clinical management of women who screen positive for human papillomavirus (HPV) infection in routine cervical cancer screening, an NCI-led study has shown.

blank Kreimer Receives NIH Director’s Award
Aimée R. Kreimer, senior investigator in the Infections and Immunoepidemiology Branch, received the NIH Director’s Award in the Scientific/Medical category for her outstanding achievements in human papillomavirus (HPV) research and leadership in the Costa Rica HPV Vaccine Trial.

blank Kevin Brown Awarded Scientific Tenure by the NIH
In October 2018, Kevin Brown, Ph.D., was awarded scientific tenure by the NIH and promoted to senior investigator in the Laboratory of Translational Genomics.

silhouette of children, various ages Pediatric Mortality Decreases in U.S., but Rates Still Higher than Canada and U.K.
All-cause mortality rates in the U.S. have decreased in most age and racial/ethnic groups, but rates remain higher and are improving more slowly than other high-income nations.

blank Study Provides Closer Look at Postmenopausal Bleeding and Endometrial Cancer
In the largest analysis to date looking at the extent to which vaginal bleeding is associated with endometrial cancer in post menopausal women, 90% endometrial cancer patients reported bleeding before diagnosis.

Davis Lynn Recognized by Rising Star in Biomedical Research
Brittny Davis Lynn was selected as a 2018 Rising Star in Biomedical Research and has been invited to speak at a related training workshop for female and under-represented minorities in biomedical research.