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Our Research

photograph of two Black women talking, a doctor and patient

PRS Improves Risk Prediction for Black Women

Breast cancer risk prediction improved with addition of a polygenic risk score.
silhouette of a woman's head composed of mosaic tiles, some of which are partially deteriorated, referencing the central thesis of the paper: mosaic X chromosome loss in women

Inherited Factors and Mosaic Loss of X

NCI Media Advisory summarizes research on the influence of inherited factors on mLOX.

DCEG's Commitment to Collaboration

Discovering the causes of cancer and the means of prevention

DCEG’s multidisciplinary research covers most types of cancer and many exposures in a variety of populations. Our cadre of inhouse scientists – epidemiologists, geneticists, biostatisticians, and clinicians – form interdisciplinary teams to study complex questions. DCEG forms collaborative partnerships within the NIH/NCI intramural research program and with scientists at academic and medical institutions around the world, which enables it to carry out its research.

The results of our research have served to inform public policy and have played an important role in improving public health.

Search DCEG publications.

  • Cancer Types Studied in DCEG

    DCEG investigators conduct research on many types of cancer to better understand the underlying causes of each disease. In addition, they study second primary cancers among cancer survivors.

  • What We Study

    DCEG research covers a range of exposures and risk factors for cancer, giving priority to emergent issues identified through epidemiologic, clinical, and laboratory observations, as well as public health concerns.

  • Who We Study

    DCEG research is carried out within a variety of research settings: population-based or occupational cohorts, case-control design studies, or families with cancer predisposition syndromes.

  • How We Study

    DCEG investigators utilize and develop methods for a variety of research approaches, from genome-wide association studies, exposure assessment, metabolomics, risk modeling, and tumor profiling.

  • Active Clinical Studies

    The following DCEG studies are open to enrollment. These observational studies of families with a known or suspected cancer predisposition syndrome, or families that have a higher-than-expected rate of cancer. Studies of families provide etiologically informative observations and assessments of cancer events over time.

  • Public Health Impact of DCEG Research

    DCEG research findings have had a significant impact on public health – both national and global.

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