Statistical methods for studying disease etiologic heterogeneity - Dr. Molin Wang
DCEG Events
October 19, 2017 | 10:30 AM – 11:30 AM
NCI Shady Grove Rockville, Maryland
Speaker
Molin Wang, Ph.D.
Assistant Professor
Departments of Biostatistics and Epidemiology,
Harvard T.H. Chan School of Public Health
Department of Medicine, Harvard Medical School
Description
A fundamental goal of epidemiologic research is to investigate the relationship between exposures and disease risk. Cases of the disease are often considered a single outcome, and assumed to share a common etiology. However, evidence indicates that many human diseases arise and evolve through a range of heterogeneous molecular pathologic processes, influenced by diverse exposures. In this talk, Dr. Wang will discuss design and analytic options for studying disease etiologic heterogeneity, emphasizing methods for evaluating whether the association of a potential risk factor with disease varies by disease subtype. Methods will be discussed for scenarios where disease subtypes are categorical and ordinal, scenarios where disease subtypes are defined by multiple markers, where disease subtypes data are missing or misclassified among some cases, and for cohort studies, matched and unmatched case-control studies, and case-case study designs. For illustration, the methods are applied to a molecular pathological epidemiology study of colorectal cancer.
Host
Mitchell H. Gail, M.D., Ph.D., Senior Investigator, Biostatistics Branch,
Division of Cancer Epidemiology and Genetics, National Cancer Institute
WebEx Information
Join WebEx meeting
Meeting number (access code): 739 984 853
Host key: 444424
Meeting password: SeminarDCEG17*
Join by phone
1-650-479-3207 Call-in toll number (US/Canada)
Global call-in numbers
Can't join the meeting? Contact support.
IMPORTANT NOTICE: Please note that this WebEx service allows audio and other information sent during the session to be recorded, which may be discoverable in a legal matter. You should inform all meeting attendees prior to recording if you intend to record the meeting.