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Cancer Epidemiology: From Pedigrees to Populations

In May 2014, NCI’s Division of Cancer Epidemiology and Genetics (DCEG) hosted Cancer Epidemiology: From Pedigrees to Populations, a scientific symposium honoring 50 years of visionary leadership by Dr. Joseph F. Fraumeni, Jr., the founding Director of DCEG. The conference provided an opportunity for scientific exchange by the leading experts in cancer epidemiology. Speakers highlighted critical findings made over the past 50 years, as well as opportunities for future research that have the potential to significantly advance our understanding of the causes of cancer. 

Speaker Presentations (Video)


Stephen J. Chanock, M.D., Director, DCEG, National Cancer Institute

SESSION I: "Search for cancer susceptibility genes"

Moderator: David Schottenfeld, M.D., University of Michigan

  • "Li-Fraumeni syndrome: Discovery and future challenges"
    Louise C. Strong, M.D., University of Texas MD Anderson Cancer Center
  • "Li-Fraumeni syndrome: TP53 and beyond"
    David Malkin, M.D., The Hospital for Sick Children
  • "Family studies, cancer etiology, and telomere biology"
    Sharon A. Savage, M.D., National Cancer Institute
  • "A tale of two genomes: Current generation approaches to cancer susceptibility"
    Kenneth Offit, M.D., M.P.H., Memorial Sloan Kettering Cancer Center

SESSION II: "High-risk populations and insights into carcinogenic mechanisms"

Moderator: Margaret R. Spitz, M.D., M.P.H., Baylor College of Medicine

  • "Transplant-associated immunosuppression and cancer"
    Eric A. Engels, M.D., M.P.H., National Cancer Institute
  • "Hormonal carcinogenesis across the life course"
    Robert N. Hoover, M.D., Sc.D., National Cancer Institute

SESSION III: "Global health: Opportunities for epidemiologic research"

Moderator: Brian E. Henderson, M.D., University of Southern California

  • "Using geographic patterns to discover environmental carcinogens"
    William J. Blot, Ph.D., International Epidemiology Institute & Vanderbilt University
  • "Lung cancer and indoor air pollution in China"
    Nathaniel Rothman, M.D., M.P.H., M.H.S., National Cancer Institute
  • "Polycyclic hydrocarbons: A unifying hypothesis for global patterns of esophageal cancer?"
    Christian C. Abnet, Ph.D., M.P.H., National Cancer Institute


  • Michael Thun, M.D., M.S., American Cancer Society
  • Michael M. Gottesman, M.D., National Institutes of Health
  • Harold E. Varmus, M.D., National Cancer Institute
  • Joseph F. Fraumeni, Jr., M.D., National Cancer Institute

Learn more details about this symposium