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Discovering the causes of cancer and the means of prevention

Clinical Genetics Branch

Saving lives and improving the quality of life for individuals at increased genetic risk of cancer.

Clinical Genetics Branch (CGB) investigators study individuals at high genetic risk of cancer in order to improve our understanding of cancer etiology and to advance clinical care. This work is carried out through two major research approaches: familial studies and clinical genetics. Read about some of our contributions to improving public health for these high-risk individuals.  

Research Mission

CGB's research mission is to conduct multidisciplinary research to advance our understanding of the molecular pathogenesis of cancer and to translate this knowledge into effective clinical applications for cancer-prone individuals and families, and for individuals at increased risk of cancer from the general population. Learn about specific CGB research areas.

Clinical Epidemiology Unit

The Clinical Epidemiology Unit (CEU) within CGB conducts etiologic research with potential clinical and public health applications, and leads studies evaluating population-based early detection and cancer prevention strategies.


CGB fellows work with researchers engaged in conducting clinical research studies targeting high-risk families, in pursuing astute clinical observations of unusual cancer occurrences that might provide new clues to cancer etiology, and in applying epidemiologic methods to the study of high-risk individuals. Meet the current CGB fellows and learn about research training opportunities in CGB.

CGB Highlights

Tucker MA, Elder DE, Curry M, et al. Risks of melanoma and other cancers in melanoma-prone families over 4 decades.

Clarke MA, Gradissimo A, Schiffman M, et al. Human papillomavirus DNA methylation as a biomarker for cervical precancer: Consistency across 12 genotypes and potential impact on management of HPV-positive women.

Koster R, Panagiotou OA, Wheeler WA, et al. Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients.

Chaturvedi AK, Graubard BI, Broutian T, et al. Effect of prophylactic human papillomavirus (HPV) vaccination on oral HPV infections among young adults in the United States.

Alter BP, Giri N, Savage SA, et al. Cancer in the National Cancer Institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up.

Gadalla SM, Aubert G, Wang T, et al. Donor telomere length and causes of death after unrelated hematopoietic cell transplantation in patients with marrow failure.