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Discovering the causes of cancer and the means of prevention
 

Sharon A. Savage, M.D.

DCEG Clinical Director
Branch Chief
Senior Investigator
Division of Cancer Epidemiology & Genetics

NCI Shady Grove | Room 6E454

Biography

Dr. Savage joined the Clinical Genetics Branch, DCEG, NCI in 2006 as a tenure-track investigator. She was awarded scientific tenure by the NIH and appointed senior investigator in 2012. In 2013, she was promoted to Branch Chief, and in 2018, she became the Clinical Director for DCEG. Dr. Savage received her M.D. from the University of Vermont College of Medicine, completed residency training in Pediatrics at Children’s National Medical Center, in Washington DC, and a fellowship in Pediatric Hematology/Oncology at the NCI Pediatric Oncology Branch and Johns Hopkins University. She is board-certified in both Pediatrics and Pediatric Hematology-Oncology. 

Dr. Savage is an elected member of the American Society for Clinical Investigation. Her current research is focused on the genetic and molecular epidemiology of telomere biology, pediatric cancer etiology, and inherited cancer predisposition syndromes.

Research Interests

Telomere Molecular Epidemiology

Video: Telomere Biology and Cancer Risk

Watch as investigators and families they study discuss dyskeratosis congenita, a rare and complex inherited cancer predisposition syndrome.

Highlights from Telomere Biology and Cancer Risk (3:25)

Telomere Biology and Cancer Risk (full length) (19:45)

Telomeres, specialized structures consisting of long DNA nucleotide repeats and a protein complex, are designed to protect the ends of chromosomes and are critical to chromosome stability. Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Eventually, telomeres become critically short, causing cellular senescence or cellular crisis, which result in apoptosis, genomic instability or a reduction in cellular lifespan. If cells bypass natural processes and continue to divide despite the presence of genomic instability, cancer can develop. Dr. Savage investigates the connection between telomere biology and cancer through studies of the association between telomere length and cancer risk, the telomere biology disorder dyskeratosis congenita, and the genetic contribution to telomere biology.

Understanding Cancer Etiology - Osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor and typically occurs during the adolescent growth spurt. Patients with localized osteosarcoma at diagnosis have a 60 to 80% long-term survival rate; metastatic disease carries a much poorer prognosis. In order to better understand the etiology of this disease, Dr. Savage conducts epidemiologic and genetic studies of osteosarcoma.

Telomeres in Li-Fraumeni Syndrome

Sharon Savage, M.D., Clinical Genetics Branch Chief, discussed "Telomeres in Li-Fraumeni Syndrome" in a Bench to Bedside program update during NIH Rare Disease Day, January 2016. 

Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is a highly-penetrant autosomal dominant cancer predisposition syndrome associated with a wide range of cancer types which occur at younger-than-expected ages. It was first described in 1969 and germline mutations in TP53 were recognized as the primary cause in 1990. Dr. Savage and her colleagues have initiated a new clinical, genetic, and epidemiologic study of LFS in order to further characterize the clinical and molecular consequences of this disorder, and to develop a cancer screening program for TP53 mutation carriers (www.lfs.cancer.gov). They also assisted in the creation of an international LFS research consortium.

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