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Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

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Li-Fraumeni Syndrome Study (LFS)

Li-Fraumeni Syndrome (LFS) is an inherited disorder that leads to a higher risk of certain cancers, including sarcomas, brain tumors, breast cancer, and many others. It is inherited in an autosomal dominant manner and is often the result of heritable changes in the TP53 gene. The NCI has evaluated families with LFS since the syndrome was first recognized in 1969. DCEG is now expanding this research through a clinical study and participation in a multi-institutional collaboration.

The LFS study is open to patient enrollment. (LFS study protocol: 11-C-0255)

Li-Fraumeni Syndrome Study – Research Publications

For more information, contact Payal Khincha.

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