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Discovering the causes of cancer and the means of prevention

Laboratory of Translational Genomics Opportunities with Specific Investigators

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Investigating Genetic Variants Underlying Risk of Melanoma and Renal Cell Cancer
Investigating Genetic Variants Underlying Risk of Pancreatic Cancer

Investigating Genetic Variants Underlying Risk of Melanoma and Renal Cell Cancer

A postdoctoral position is available in the Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, within the laboratory of Kevin Brown, Ph.D.

The main interest of our laboratory focuses on inherited predisposition to melanoma and renal cell cancer, and functional characterization of common and infrequent risk variants identified by genome-wide association studies (GWAS) and sequencing-based approaches. We are members of the International Melanoma Genetics Consortium (GenoMEL) and collaborate in the areas of GWAS and family-based studies of melanoma risk, as well as lead ongoing melanoma and renal cell cancer GWAS efforts at the National Cancer Institute.

Specifically, this opening is for a highly motivated individual interested in functional and translational laboratory investigations to identify target genes and understand the functional consequences of carrying melanoma and or renal cancer risk variants. We apply both targeted and genome-wide (e.g. RNA sequencing, ChIP sequencing, methylation arrays) genetic and epigenetic methods to evaluate potential functional risk variants within associated chromosomal regions. We also apply cell biological methods to evaluate the phenotypic consequences of altered regulation of susceptibility genes on phenotypes associated with cancer progression.

Qualifications

Candidates should have a Ph.D. in molecular biology, genetics, cell biology, or biochemistry and no more than five years of postdoctoral experience. We seek self-motivated individuals who have an excellent understanding of molecular and cellular biology and experience in the analysis of gene expression, transcriptional control, gene regulatory elements, protein function, signal transduction and growth control. Aptitude for genomic data analysis and an understanding of genetics and genomics is a plus, as well as a strong publication record and effective written and verbal communication skills.

For more information, contact Dr. Brown.

See the Division Fellowship Information page for a general overview, qualifications, and application details.

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Investigating Genetic Variants Underlying Risk of Pancreatic Cancer

A postdoctoral position is available in the laboratory of Laufey Amundadottir, Ph.D., senior investigator, in the Laboratory of Translational Genomics (LTG), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), NIH.

The main interest of our laboratory focuses on inherited predisposition to pancreatic cancer, and functional characterization of common and infrequent risk variants identified by genome-wide association studies (GWAS) and sequencing-based approaches. We lead genetic studies conducted within the international Pancreatic Cancer Cohort Consortium (PanScan) and collaborate with research groups worldwide in the areas of GWAS and family-based studies of pancreatic cancer risk.

This opening is for a highly motivated individual interested in functional and translational laboratory investigations to understand the functional consequences of carrying inherited pancreatic cancer risk variants. We apply both targeted and genome-wide genetic and epigenetic methods to evaluate potential functional risk variants within associated chromosomal regions as well as molecular and cell biological methods to evaluate the phenotypic consequences of altered regulation of susceptibility genes on phenotypes associated with cancer progression.

Qualifications

Candidates should have a Ph.D. in molecular biology, genetics, cell biology, or biochemistry and no more than five years of postdoctoral experience. We seek self-motivated individuals with an excellent understanding of molecular and cellular biology and experience in the analysis of gene expression, transcriptional control, gene regulatory elements, protein function, signal transduction and growth control. Aptitude for genomic data analysis and an understanding of genetics and genomics is a plus, as well as a strong publication record and effective written and verbal communication skills.

See the Division Fellowship Information page for a general overview and qualifications.

To apply, submit a cover letter highlighting key qualifications and interests, a current CV and 3 letters of reference to:

Laufey Amundadottir, Ph.D
Laboratory of Translational Genomics
Division of Cancer Epidemiology and Genetics
National Cancer Institute, NIH
Advanced Technology Center
8717 Grovemont Circle
Gaithersburg, MD 20892-4605
Email: amundadottirl@mail.nih.gov

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