Jinghui Zhang, Ph.D. - Therapy-Related Clonal Evolution in Pediatric Cancer Patients and Long-term Survivors
ITEB Seminar Series/Emerging Approaches for Tumor Analyses in Epidemiological Studies Workshop
July 13, 2023 | 10:30 AM – 11:30 AM
Jinghui Zhang, Ph.D.
St. Jude Children’s Research Hospital
Department of Computational Biology
Therapy-Related Clonal Evolution in Pediatric Cancer Patients and Long-term Survivors
Dr. Maria Teresa Landi, M.D., Ph.D., senior investigator, ITEB, and senior advisor for genomic epidemiology, TDRP
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About the Speaker
Dr. Jinghui Zhang is the Chair of Department of Computational Biology and Endowed Chair of Bioinformatics at St. Jude Children’s Research Hospital. Her research is to understand the effect of genetic alterations on cancer. Major accomplishments include mapping the landscapes of >20 pediatric cancers; development of novel algorithms leading to discoveries of targetable kinase fusion, novel oncogenic fusion, non-coding driver variants; defining germline cancer predisposition mutations in pediatric cancer; implementing an integrated clinical sequencing pipeline; and performing the first pan-pediatric cancer analysis unveiling striking difference in mutational signature and driver gene landscape of pediatric versus adult cancer. Her lab has discovered the therapy-related mutational signatures in relapsed acute lymphoblastic leukemia, osteosarcoma and most recently, survivors of pediatric cancer. An advocate for genomic data sharing, she has developed the St. Jude Cloud which now hosts multi-omics data generated from >10,000 pediatric cancer patients. Dr. Zhang is a recipient of the 2019 AACR Team Science Award and one of the most highly cited scientists in the last decade with a total of >150,000 citations.