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Discovering the causes of cancer and the means of prevention
 

Cancer Genomics Research Laboratory

The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of DCEG's research. Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG’s intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer.  

CGR's high throughput laboratory is equipped with state-of-the-art laboratory equipment and automation systems for a large number of applications. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, development and implementation of bioinformatic pipelines, and downstream scientific research and analytical support.

Research Areas

Utilizing the newest technologies, CGR conducts scientific research in support of DCEG investigators via genomic and analytical resources across a variety of applications, including:

  • DNA extraction and sample handling services
  • Design, execution and analysis for genome wide association studies
  • Validation and replication utilizing targeted genotyping techniques
  • Epigenetic studies utilizing array-based methylation analysis
  • Telomere length assessment
  • Evaluation of copy number variation
  • Whole exome sequencing and analysis for familial and population germline studies
  • Regional and targeted sequencing applications

Research Highlights

Gouveia MH, Borda V, Leal TP, et al. Origins, admixture dynamics and homogenization of the African gene pool in the AmericasMol Biol Evol 2020 Jun 1.
 
Lou H, Boland JF, Torres-Gonzalez E, et al. The D2 and D3 sublineages of human papillomavirus 16-positive cervical cancer in Guatemala differ in integration rate and age of diagnosis. Cancer Res 2020 Sep 15 (Epub Jul 6).

Wang M, Luo W, Jones K, et al. SomaticCombiner: Improving the performance of somatic variant calling based on evaluation tests and a consensus approach. Sci Rep 2020 Jul 30.

Pinheiro M, Gage JC, Clifford GM, et al. Association of HPV 35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with implications for disease intervention. Int J Cancer 2020 Nov 15; Epub May 16.