Laboratory of Genetic Susceptibility
Understanding the genetic underpinnings of susceptibility to cancer
The Laboratory of Genetic Susceptibility (LGS) performs interdisciplinary research on cancer genetics and susceptibility.
The LGS mission is to understand the biological basis for genetic susceptibility to cancer, including:
- Identification and characterization of cancer susceptibility alleles
- Characterization of the scope of genetic mosaicism and its contribution to cancer risk
- Investigation of the genetic architecture of cancer susceptibility
- Determination of how germline variation informs our understanding of somatic alterations in cancer
LGS scientists participate in genetic, epidemiologic, clinical and methodological studies of populations, families, and persons at risk for cancer. In addition, they collaborate and consult with experts in statistical genetics, bioinformatics, genetic epidemiology, and molecular epidemiology in interdisciplinary studies.
Essential to the mission of the Laboratory is a close collaboration with the NCI-Frederick Cancer Genomics Research Laboratory (CGR). Formerly known as the Core Genotyping Facility (CGF), this laboratory designs and conducts high throughput sequencing, genotyping, and analysis in support of large scale epidemiologic studies.
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Zhou W, Machiela MJ, Freedman ND, et al. Mosaic loss of chromosome Y is associated with common variation near TCL1A . Nat Genet 2016.