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Discovering the causes of cancer and the means of prevention

Cancer Genomics Research Laboratory

The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of DCEG's research. Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG’s intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer.  

CGR's high throughput laboratory is equipped with state-of-the-art laboratory equipment and automation systems for a large number of applications. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, development and implementation of bioinformatic pipelines, and downstream scientific research and analytical support.

Research Areas

Utilizing the newest technologies, CGR conducts scientific research in support of DCEG investigators via genomic and analytical resources across a variety of applications, including:

  • DNA extraction and sample handling services
  • Design, execution and analysis for genome wide association studies
  • Validation and replication utilizing targeted genotyping techniques
  • Epigenetic studies utilizing array-based methylation analysis
  • Telomere length assessment
  • Evaluation of copy number variation
  • Whole exome sequencing and analysis for familial and population germline studies
  • Regional and targeted sequencing applications

Research Highlights

Hansen MEB, Rubel MA, Bailey AG, et al. Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana. Genome Biol 2019 Jan 22.
Zhou W, Machiela MJ, Freedman ND, et al. Reply to 'Mosaic loss of chromosome Y in leukocytes matters'. Nat Genet 2019 Jan.

Gianferante DM, Rotunno M, Dean M, et al. Whole-exome sequencing of nevoid basal cell carcinoma syndrome families and review of Human Gene Mutation Database PTCH1 mutation data. Mol Genet Genomic Med 2018 Nov.

Dagnall CL, Morton LM, Hicks BD, et al. Successful use of whole genome amplified DNA from multiple source types for high-density Illumina SNP microarrays. BMC Genomics 2018 Mar 6.

Mirabello L, Clarke MA, Nelson CW, et al. The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis. Viruses 2018 Feb 13.