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Discovering the causes of cancer and the means of prevention

Integrative Tumor Epidemiology Branch

The Integrative Tumor Epidemiology Branch (ITEB) employs molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.

Research Mission

The mission of ITEB is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies.


ITEB provides a dynamic and collaborative environment for trainees at the pre- and post-doctoral level. Meet the current ITEB fellows and learn about research training opportunities in ITEB.

ITEB Highlights

Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast densityNPJ Breast Cancer 2019; Mullooly M, Ehteshami Bejnordi B, Pfeiffer RM, et al.  

Comparative validation of breast cancer risk prediction models and projections for future risk stratification J Natl Cancer Inst  2019. Choudhury PP, Wilcox AN, Brook MN, et al. 

Immune gene expression profiling reveals heterogeneity in luminal breast tumorsBreast Cancer Res 2019. Zhu B, Tse LA, Wang D, et al. 

Fine Mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicityNat Commun 2018. Ferreiro-Iglesias A, Lesseur C, McKay J, et al. 

Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. Int J Cancer 2018; Abubakar M, Chang-Claude J, Ali HR, et al.

Mosaic Y loss is moderately associated with solid tumor risk. Cancer Res 2019; Loftfield E, Zhou W, Yeager M, et al.

Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma. Hum Mol Genet 2018; Gu F, Chen TH, Pfeiffer RM, et al.