Integrative Tumor Epidemiology Branch
The Integrative Tumor Epidemiology Branch (ITEB) employs molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.
The mission of ITEB is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies.
Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast. npj Breast Cancer 2020; Bodelon C, Oh H, Derkach A, et al.
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. Nat Commun 2020; Zhang YD, Hurson AN, Zhang H, et al.
Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma. Nat Commun 2020; Hua X, Zhao W, Pesatori AC, et al.
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nat Genet 2020; Landi MT, Bishop DT, MacGregor S, et al.
Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men. Sci Rep 2020; Lin SH, Loftfield E, Sampson JN, et al.