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Discovering the causes of cancer and the means of prevention

Integrative Tumor Epidemiology Branch

The Integrative Tumor Epidemiology Branch (ITEB) employs molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.

Research Mission

The mission of ITEB is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies.


ITEB provides a dynamic and collaborative environment for trainees at the pre- and post-doctoral level. Meet the current ITEB fellows and learn about research training opportunities in ITEB.

ITEB Highlights

Comparative validation of breast cancer risk prediction models and projections for future risk stratification J Natl Cancer Inst  2019. Choudhury PP, Wilcox AN, Brook MN, et al. 

Fine Mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicityNat Commun 2018. Ferreiro-Iglesias A, Lesseur C, McKay J, et al. 

Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies. Mod Pathol 2018; Ehteshami Bejnordi B, Mullooly M, Pfeiffer RM, et al.

Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. Int J Cancer 2018; Abubakar M, Chang-Claude J, Ali HR, et al.

Mosaic Y loss is moderately associated with solid tumor risk. Cancer Res 2019; Loftfield E, Zhou W, Yeager M, et al.

Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma. Hum Mol Genet 2018; Gu F, Chen TH, Pfeiffer RM, et al.