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Discovering the causes of cancer and the means of prevention

Integrative Tumor Epidemiology Branch

The Integrative Tumor Epidemiology Branch (ITEB) employs molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.

Research Mission

The mission of ITEB is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies.


ITEB provides a dynamic and collaborative environment for trainees at the pre- and post-doctoral level. Meet the current ITEB fellows and learn about research training opportunities in ITEB.

ITEB Highlights

Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women. N Engl J Med 2021; Breast Cancer Association Consortium.

Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival. Nat Commun 2021; Bai J, Shi J, Li C, et al.

Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never Smokers: the Sherlock-Lung Study. American Journal of Epidemiology 2020; Landi MT, Synnott NC, et al. 

Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast. NPJ Breast Cancer 2020; Bodelon C, Oh H, Derkach A, et al.

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma. Nat Commun 2020; Hua X, Zhao W, Pesatori AC, et al.

Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibilityNat Genet 2020; Landi MT, Bishop DT, MacGregor S, et al.