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Integrative Tumor Epidemiology Branch

The Integrative Tumor Epidemiology Branch (ITEB) employs molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.

Research Mission

The mission of ITEB is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies. Learn more about the research in ITEB.


ITEB provides a dynamic and collaborative environment for fellows at the pre- and postdoctoral levels.

Meet the current ITEB fellows and learn about research training opportunities in ITEB.

ITEB Highlights

Enduring Guidelines: Methods and Dual Stain for Cervical Cancer Screening Triage

Machiela, M., et al. GWAS Explorer: An open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO AtlasScientific Data, 2023.

Davis Lynn BC, et al. Associations between quantitative measures of TDLU involution and breast tumor molecular subtypes among breast cancer cases in the Black Women’s Health Study: a case–case analysis. Breast Cancer Research 2022.

The PLCO Atlas, part of GWAS Explorer, accelerates innovative analysis of GWAS results through a dynamic framework of interactive visualizations designed to aid in uncovering novel connections and spark new avenues of investigation.

Brown D, et al. Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis. Nature Commun. 2022.

Zhang T, et al. Genomic and evolutionary classification of lung cancer in never smokersNat Genetics 2021.

Zekavat S, et al. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med. 2021.

Bai J, et al. Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival. Nat Commun. 2021.

Landi MT, et al. Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never Smokers: the Sherlock-Lung Study. Am J Epidemiol. 2020.

Landi MT, et al. Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibilityNat Genet. 2020.