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Integrative Tumor Epidemiology Branch

The Integrative Tumor Epidemiology Branch (ITEB) employs molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.

Research Mission

The mission of ITEB is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies. Learn more about the research in ITEB.


ITEB provides a dynamic and collaborative environment for fellows at the pre- and postdoctoral levels.

Meet the current ITEB fellows and learn about research training opportunities in ITEB.

ITEB Highlights

Liu A, et al. Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection. Nature. 2024.

Vo JB et al. Long-term cardiovascular disease risk after anthracycline and trastuzumab treatments in U.S. breast cancer survivorsJ Natl Cancer Inst. 2024

Mullooly M, et al. Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease. Breast Cancer Res. 2024.

Purdue MP, et al. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nat Genet. 2024.

Machiela M, et al. GWAS Explorer: An open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas. Scientific Data. 2023.

Lee OW, et al. Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding. Am J Hum Genet. 2023.

Zhang T, et al. Genomic and evolutionary classification of lung cancer in never smokers. Nat Genetics. 2021.

Bai J, et al. Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival. Nat Commun. 2021.