Genetics and Genomics of Melanoma Susceptibility Postdoctoral Fellowship

Work with Kevin Brown, Ph.D.

The NCI Division of Cancer Epidemiology and Genetics is recruiting a postdoctoral fellow to join the research laboratory of Kevin Brown, Ph.D., senior investigator in the Laboratory of Translational Genomics. The lab studies the genetics underlying melanoma susceptibility and melanoma risk-associated phenotypes, focusing on translation of findings from genetic epidemiological studies including genome-wide association studies (GWAS) and family sequencing studies. The lab's scientists are members of multiple international melanoma genetics research consortia and actively collaborate on both large-scale genetic studies as well as functional studies stemming from consortia findings.  

This position offers the opportunity to investigate genetic mechanisms underlying cancer susceptibility in both high-risk families and the general population, focusing on identifying causal variants, susceptibility genes, and biological pathways, as well as functional interactions with environmental risk factors (ultraviolet radiation). Lab members apply multiple scalable genetic and genomics-based approaches, including molecular quantitative trait locus (QTL) analyses, ChIP-seq, DNA methylation, Hi-C, Hi-ChIP, ATAC-seq, single-cell sequencing, as well as scalable functional genomics approaches including CRISPR screens and sequencing-based massively parallel reporter assays. They also use conventional molecular and cell biological methods to evaluate the phenotypic consequences of altered regulation of susceptibility genes on phenotypes associated with cancer progression in-depth. 

The successful candidate will have the opportunity to lead studies investigating melanoma risk. The fellow will be mentored to learn new methods and approaches in genetics, genomics, and molecular and cellular biology, and will have the opportunity to work closely with researchers with expertise in epidemiology, biostatistics, bioinformatics, and genetics both within and outside of NIH. The fellow also will have opportunities for additional training in informatics and other relevant biological fields, as well as the chance to gain experience mentoring postbaccalaureate fellows and or summer students.

Learn more about the advantages of being a DCEG fellow, including our distinctive research environment, mentorship, professional development, compensation and benefits, and commitment to diversity and inclusion.  Find more information about Dr. Brown's research laboratory, including lab members. 

Qualifications

Candidates must have completed or will soon complete a Ph.D. or equivalent degree with an emphasis in molecular biology, cell biology, cancer biology, human genetics, population genetics, or related areas within the past five years. We seek self-motivated researchers with experience in genomics and/or molecular biology, an interest in applying cutting edge ‘omics approaches, a demonstrated ability to work in a multidisciplinary and diverse team, and clear communication skills. Experience with basic bioinformatics and large datasets is helpful but not required. Salary will be determined based on the NCI stipend schedule for postdoctoral fellows. 

To Apply

For more details on this opportunity, or to apply with a cover letter, CV, and contact information of three references, please contact Kevin Brown, Ph.D., senior investigator. 

Review of applications will continue until the position is filled. Applicants may be U.S. citizens, permanent residents; or foreign nationals (visa requirements apply). Candidates are subject to a background investigation. 

To explore other translational genomics fellowships, see the Translational Genomics Fellowship Opportunities page.