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Genomic Studies of Pediatric Cancers
Cancer Genomics of Lymphoproliferative or Gastrointestinal Cancers
Integrating Genomic and Epidemiological Data in Understanding Disease Outcome
Inherited Bone Marrow Failure Syndromes of Childhood
The Clinical Genetics Branch is seeking a postdoctoral fellow with an interest in conducting genomic studies to identify susceptibility genes and modifier factors for pediatric cancers. The goal of our research is to identify and characterize genetic variants that underlie the development of pediatric cancers and patient outcomes. The potential fellow will use bioinformatic, genetic, epidemiologic, and/or biostatistic methods to analyze complex data derived from genome-wide association and next-generation sequencing (e.g., whole-exome sequencing) pediatric cancer studies.
The candidate will have the opportunity of working closely with researchers with expertise in pediatric cancer, epidemiology, biostatistics, bioinformatics, genetics, and genomics. DCEG fellows have access to data from state-of-the-art studies in cancer genomics and work with highly committed and talented researchers. DCEG offers extensive career development training through its Office of Education.
Qualifications: Applicants with a doctoral degree and background in genetics/genomics, genetic epidemiology, or statistical genetics are encouraged to apply. Candidates with a doctoral degree in related fields with strong quantitative skills are also encouraged to apply. Experience in analyses of large genomic datasets, next-generation sequencing, and/or bioinformatics methods is required. A successful candidate will have excellent communication skills, be highly motivated and able to work in a large multidisciplinary team. Salary and benefits are competitive and commensurate with experience.
To apply: See the Division Fellowship Information page for an overview, qualifications, and application details.
Investigators in the Clinical Genetics Branch are seeking a postdoctoral fellow with an interest in conducting multi-omics analyses to identify major susceptibility genes and modifier factors for lymphoproliferative and gastrointestinal cancers. The potential fellow will be analyzing high-dimensional germline genomic data (e.g., whole-exome sequencing, SNP array, RNASeq, methylation array) derived primarily from multi-generational families with lymphoproliferative or gastrointestinal diseases, such as lymphoma, leukemia, Waldenström macroglobulinemia, and esophageal, gastric, or pancreatic cancer. The candidate will have the opportunity of working closely with researchers with expertise in epidemiology, biostatistics, bioinformatics, genetics, and genomics and will have extensive career development training opportunities through the DCEG Office of Education.
Qualifications: Applicants with a doctoral degree in genetic epidemiology, statistical genetics, bioinformatics, or biostatistics are preferred. Candidates with a doctoral degree in related fields with strong quantitative skills are also encouraged to apply. Experience in analyses of lymphoproliferative diseases, gastrointestinal cancer or omics data is a plus.
To Apply: See the Division Fellowship Information page for an overview, qualifications, and application details.
Cancer Risk in Myotonic Dystrophy: Investigators at the Clinical Genetics Branch were the first to report epidemiological evidence of excess cancer risk in patients with the neuromuscular disorder, myotonic dystrophy (DM). This work identified DM as a new cancer susceptibility syndrome. Our current research aims at understanding the cancer risk factors and the molecular mechanisms behind this observation.
Predictors of Outcomes After Hematopoietic Cell Transplantation (HCT): Our work in this area has identified donor telomere length as an important predictor for patient survival after HCT for severe aplastic anemia. We are expanding our work to include other diseases and to identify novel genomic predictors associated with patient outcome after HCT.
Qualifications: Applicants with a doctoral degree in genetics/genomics, epidemiology, or related field are encouraged to apply. Experience in analyses of large-scale genomic sequence data is a plus. A successful candidate will work with highly committed and talented researchers with expertise in epidemiology, biostatistics, and genomics, and will have extensive career development training opportunities through the DCEG Office of Education. Salary and benefits are highly competitive and commensurate with experience.
For More Information: contact Shahinaz Gadalla, M.D., Ph.D.
To Apply: See the Division Fellowship Information page for general overview, qualifications, and application details.
CGB is seeking a clinically-trained pediatric or medical hematology/oncology physician with research interests in the Inherited Bone Marrow Failure disorders, e.g., Fanconi anemia, dyskeratosis congenita, Diamond Blackfan anemia, Shwachman Diamond syndrome, Thrombocytopenia Absent Radii syndrome, etc., who desires a postdoctoral research opportunity which is focused on these rare conditions.
The Branch is now more than 15 years into assembling and analyzing the world's largest cohort of affected families, systematically collecting demographic, medical, epidemiologic, genetic, and psychosocial/behavioral data plus carefully-annotated biospecimens, to support etiologically-oriented translational research. This includes the opportunity to learn the clinical phenotype of these diseases first-hand, participate in the evaluation of clinical research protocol participants, become involved in the analysis and publication of data derived from this cohort, and acquire new skills related to clinical genetics and epidemiology.
Qualifications: Individuals with clinical training in pediatric or medical hematology/oncology or genetics who also have a strong interest in inherited bone marrow failure and cancer predisposition syndromes are sought for this position. Previous training or experience in genetics, epidemiology, and/or biostatistics would be highly beneficial, although not required.
See the Division Fellowship Information page for general overview, qualifications, and application details.
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