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Discovering the causes of cancer and the means of prevention

Infections and Immunoepidemiology Branch

Improving health by conducting high impact epidemiological research on infectious agents and cancer

IIB Highlights

Shiels MS, Islam JY, Rosenberg PS, et al. Projected cancer incidence rates and burden of incident cancer cases in HIV-infected adults in the United States through 2030. Ann Intern Med 2018

Safaeian M, Sampson JN, Pan Y, et al. Durability of protection afforded by fewer doses of the HPV 16/18 vaccine: The CVT trial. J Natl Cancer Inst 2018

Shiels MS, Chernyavskiy P, Anderson WF, et al. Trends in premature mortality in the USA by sex, race, and ethnicity from 1999 to 2014: An analysis of death certificate data. Lancet 2017

Kreimer AR, Johansson M, Yanik EL, et al. Kinetics of the human papillomavirus type 16 E6 antibody response prior to oropharyngeal cancer. J Natl Cancer Inst 2017

Koshiol J, Gao YT, Dean M, et al. Association of aflatoxin and gallbladder cancer. Gastroenterology 2017

Yanik EL, Smith JM, Shiels MS, et al. Cancer risk after pediatric solid organ transplantation. Pediatrics 2017


Investigators in the Infections and Immunoepidemiology Branch (IIB) conduct multidisciplinary studies of carefully selected domestic and foreign populations, with the goal of clarifying the relationship of infectious agents, especially viruses, to human cancer and other conditions. (Cell illustration credit: Kristy Whitehouse)

Research Mission

IIB’s research mission is to discover infectious causes of cancer, to elucidate the determinants of malignancy for established oncogenic infections, to uncover novel infection-cancer associations, and to clarify how alterations in immunity and inflammation relate to cancer risk.

IIB investigators collaborate with researchers from a variety of disciplines in the U.S. and abroad. In addition to epidemiologic and clinical data, many IIB field studies include an extensive biological specimen collection component that allows for careful molecular testing to better define both exposures and outcomes of interest

Learn more about specific IIB research areas.


Working closely with tenured and tenure-track investigators, IIB fellows take lead responsibility for analyzing and summarizing previously collected data. Senior staff assist them in writing manuscripts and bringing these to publication in the peer-reviewed scientific literature. Fellows become familiar with the entire IIB portfolio and are encouraged to participate in on-going and newly proposed studies within the Branch and throughout the Division. Meet the current IIB fellows and learn about research training opportunities in IIB.

Spotlight on IIB Investigators

Dr. Shiels and Dr. Koshiol are tenure-track investigators in IIB

Meredith Shiels and Jill Koshiol

Meredith Shiels, Ph.D., and Jill Koshiol, Ph.D., explore cancer incidence trends and mortality over time, and the role of inflammation in biliary tract cancers. Read more about IIB's tenure-track investigators.