Infections and Immunoepidemiology Branch
Improving health by conducting high-impact epidemiological research on infections, the immune system, and cancer
Investigators in the Infections and Immunoepidemiology Branch (IIB) conduct multidisciplinary epidemiologic studies to clarify the relationship of infectious agents and alterations in the immune system to human cancer. (Cell illustration credit: Kristy Whitehouse)
IIB conducts epidemiologic research on 1) infectious agents with established or postulated associations with cancer and 2) immune variation relevant for cancer risk, including conditions such as severe immunosuppression, autoimmune diseases, chronic inflammation, and genetic factors. The Branch focuses on etiologic studies and looks for opportunities to translate those findings to cancer prevention, risk stratification, screening, and clinical medicine.
IIB research has broad relevance in reducing health disparities, since certain infections related to cancer disproportionately affect people living in lower- and middle-income countries and disadvantaged groups within the United States. Approximately 15% of all cancers worldwide (23% in developing countries and 9% in developed countries) are attributable to infectious agents. Immunity and inflammation also play an important role in the etiology of cancer.
Learn more about specific IIB research areas.
Working closely with tenured and tenure-track investigators, IIB fellows take lead responsibility for analyzing and summarizing previously collected data. Senior staff assist in writing manuscripts and bringing these to publication in the peer-reviewed scientific literature. Fellows become familiar with the entire IIB portfolio and are encouraged to participate in on-going and newly proposed studies within the Branch and throughout the Division.
Stephens E et al. Human papillomavirus awareness by educational level and by race and ethnicity. JAMA Netw Open. 2023.
McGee-Avila JK et al. Risk of hepatocellular carcinoma in people with HIV in the United States, 2001-2019. J Natl Cancer Inst. 2023.
Lou P-J et al. Performance and operational feasibility of Epstein-Barr virus–based screening for detection of nasopharyngeal carcinoma: Direct comparison of two alternative approaches. J Clin Oncol. 2023.
Shing JZ, et al. Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: An analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial. Lancet Oncol 2022.
Song M, et al. Association of antiparietal cell and anti-intrinsic factor antibodies with risk of gastric cancer. JAMA Oncol 2022. Read more about the gastric cancer study.
Shiels MS, et al. Leading causes of death in the U.S. during the COVID-19 pandemic, March 2020 to October 2021. JAMA Intern Med 2022.
Lu Z, et al. HLA zygosity increases risk of hepatitis B virus-associated hepatocellular carcinoma. J Infect Dis 2021.
Engels EA, et al. Predicted cure and survival among transplant recipients with a previous cancer diagnosis. J Clin Oncol 2021.