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Discovering the causes of cancer and the means of prevention

Laboratory of Translational Genomics

Understanding the contribution of germline genetic variation to cancer etiology and outcomes

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The Laboratory of Translational Genomics (LTG) conducts studies on germline and somatic genetics of cancer, and analyses on particular regions of the genome conclusively identified in cancer-specific genome-wide association studies (GWAS) and linkage studies in high-risk families.

Research Mission

LTG's mission is to understand the contribution of germline and somatic genetic variation to cancer etiology and outcomes. Its primary goals are to investigate regions of genetic variation by:

  • Detecting cancer susceptibility alleles
  • Fine mapping susceptibility alleles using sequence analysis and imputation from public databases
  • Prioritizing variants for follow-up studies through bioinformatic analysis of candidate variants
  • Deciphering the biological mechanisms underlying susceptibility alleles through laboratory investigation

Learn more about specific LTG research areas.

Fellowships

LTG accepts fellowship applications on an ongoing basis. Meet the current LTG fellows and learn about research training opportunities in LTG.

Partnerships

Essential to the mission of the Laboratory is a close collaboration with the NCI-Frederick Cancer Genomics Research Laboratory (CGR). Formerly known as the Core Genotyping Facility (CGF), this laboratory designs and conducts high throughput sequencing, genotyping, and analysis in support of large scale epidemiologic studies.

LTG Highlights

Zhang T, Choi J, Kovacs MA, […] Brown KM.  Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.  Genome Res 2018

Petrovics G, Price DK, Lou H, […] Dean M.  Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population.  Prostate Cancer Prostatic Dis 2018

Zhang M, Lykke-Andersen S, Zhu B, […] Amundadottir L.  Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.  Gut 2018

Tang W, Wallace TA, Yi M,[…] Prokunina-Olsson L, Ambs S.  IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer.  Clin Cancer Res 2018