Laboratory of Translational Genomics

Understanding the contribution of genetic variation to cancer etiology and outcomes

The Laboratory of Translational Genomics (LTG) conducts studies on germline and somatic genetics of cancer, including analyses of regions of the human genome conclusively identified in cancer-specific genome-wide association studies (GWAS) and family-based studies.

Research Mission

The mission of the LTG is to understand the contribution of germline and somatic genetic variation to cancer etiology and outcomes and to elucidate underlying molecular mechanisms of these associations. Our primary goals are to:

• Detect cancer susceptibility alleles across multiple cancer types and ancestries
• Fine-map susceptibility alleles using sequencing, genotyping and imputation based on data from public databases
• Prioritize candidate variants for follow-up studies through bioinformatics analyses
• Decipher the biological mechanisms underlying susceptibility alleles through laboratory investigation
• Establish genomic resources representing diverse ancestries and cancer sites to facilitate cancer genomics research
• Integrate cutting-edge, high-throughput functional genomics approaches in genetic/epidemiologic studies

Research Laboratories

Each LTG investigator heads a laboratory focused on specific research.

• The Laufey Amundadottir Laboratory investigates genetic risk for pancreatic cancer.
• The Kevin Brown Laboratory focuses on understanding genetic susceptibility to melanoma.
• The Jiyeon Choi Laboratory focuses on understanding genetic susceptibility to lung cancer and melanoma.
• The Michael Dean Laboratory focuses on inherited (germline) genetic variation, and somatic mutations in tumors, and the combined effect of both on cancer risk, progression, and response to therapy.
• The Ludmila Prokunina-Olsson Laboratory explores the connections between GWAS-identified genetic susceptibility variants and molecular phenotypes of importance for cancer.