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Discovering the causes of cancer and the means of prevention

Laboratory of Translational Genomics

Understanding the contribution of germline genetic variation to cancer etiology and outcomes

LTG Highlights

Scelo G, Purdue MP, Brown KM, [...] Chanock S. Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nat. Commun 2017

Fang J, Jia J, Makowski M, [...] Amundadottir LT. Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nat Commun 2017

Nickerson ML, Das S, Im KM, et al. TET2 binds the androgen receptor and loss is associated with prostate cancer. Oncogene 2017 [Epub 2016 Nov 7]

Yang XR, Devi BCR, Sung H, [...] Dean M. Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia. Breast Cancer Res Treat 2017 [Epub ahead of print]

The Laboratory of Translational Genomics (LTG) conducts studies on germline and somatic genetics of cancer, and analyses on particular regions of the genome conclusively identified in cancer-specific genome-wide association studies (GWAS) and linkage studies in high-risk families.

Research Mission

LTG's mission is to understand the contribution of germline and somatic genetic variation to cancer etiology and outcomes. Its primary goals are to investigate regions of genetic variation by:

  • Detecting cancer susceptibility alleles
  • Fine mapping susceptibility alleles using sequence analysis and imputation from public databases
  • Prioritizing variants for follow-up studies through bioinformatic analysis of candidate variants
  • Deciphering the biological mechanisms underlying susceptibility alleles through laboratory investigation

Learn more about specific LTG research areas.


LTG accepts fellowship applications on an ongoing basis. Meet the current LTG fellows and learn about research training opportunities in LTG.


Essential to the mission of the Laboratory is a close collaboration with the NCI-Frederick Cancer Genomics Research Laboratory (CGR). Formerly known as the Core Genotyping Facility (CGF), this laboratory designs and conducts high throughput sequencing, genotyping, and analysis in support of large scale epidemiologic studies.