Research Highlights - News Updates
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Risk-based lung cancer screening may prevent more deaths than current U.S. guidelines
A study from the National Cancer Institute (NCI) offers new evidence that individualized lung cancer risk-based screening may be more effective at preventing lung cancer deaths than current U.S. Preventive Services Task Force (USPSTF) screening criteria.
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Cocaine contributes to overdose deaths among some minorities
A new study shows that cocaine is a consistent contributor to overdose deaths, in addition to opioids.
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International consortium adds 72 genetic variants to list of known breast cancer associations
An international team of scientists, known collectively as the OncoArray Network, have identified an additional 72 common inherited variants associated with risk for breast cancer.
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Utilizing Longitudinal Primary Care Patient Data to Conduct Epidemiologic Studies
DCEG investigators are utilizing data from the UK Clinical Practice Research Datalink, the world’s largest database of anonymized, longitudinal primary care medical records.
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New Regions of the Human Genome Linked to Skin Color Variation in Some African Populations
In the first study of its kind, an international team of genomics researchers has identified new regions of the human genome that are associated with skin color variation in some African populations, opening new avenues for research on skin diseases and cancer in all populations.
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Research from DCEG Study Informs New Cervical Cancer Prevention Standards
In September 2017, the American Society for Colposcopy and Cervical Pathology (ASCCP) released recommendations on new standards of colposcopy practice, based largely on findings from DCEG research.
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Whole-Genome Sequencing of HPV 16 Reveals New Criterion for Carcinogenicity
A large genomic analysis of human papillomavirus (HPV) shines new light on the influence of viral genetic diversity on carcinogenicity of the high-risk type HPV16.
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Serum ghrelin concentration linked to colorectal cancer risk
In a new study from the National Cancer Institute, researchers report an association between the hormone ghrelin, measured in blood serum, and risk of colorectal cancer in a population of male Finnish smokers.
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NCI study shows feasibility of cancer screening protocol for high-risk population
In a new study from the National Cancer Institute, researchers found a high prevalence of cancer at baseline screening in individuals with Li-Fraumeni syndrome, a rare inherited disorder that leads to a higher risk of developing certain cancers.
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Lisa Mirabello: Using Genetic Data to Understand Osteosarcoma Etiology and HPV Carcinogenicity
Profile of Lisa Mirabello in the Clinical Genetics Branch. Dr. Mirabello uses genetic data to understand osteosarcoma etiology and HPV carcinogenicity.
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Common inherited variant influences breast cancer risk after chest radiotherapy for survivors of childhood cancer
A common genetic variant is associated with higher risk of breast cancer among survivors of childhood cancer who received chest radiotherapy, according to a new study led by DCEG researchers.
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Scientific Highlights March - June 2017
Scientific papers by DCEG researchers, published from March through June, 2017
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Exploring the Relationship Between Mammographic Breast Density and Breast Cancer
Dr. Gretchen Gierach and colleagues employ a range of technologies and approaches to study mammographic breast density and its relationship to breast cancer risk.
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Applying 3-Dimensional Printing for Radiation Exposure Assessment
Researchers are using 3D printing to create tools for health physicists to improve their estimates of radiation dose for epidemiological studies.
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Exposure to Mold Toxin Linked to Gallbladder Cancer Risk
A study by the National Cancer Institute reports an association between a marker of exposure to aflatoxin, a poisonous chemical produced by a type of mold, and gallbladder cancer in a population of men and women in Shanghai, China.
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In-depth Investigation of Genetic Region Identifies Mechanism that Contributes to Cancer Susceptibility
Investigators in the Laboratory of Translational Genomics have identified a genetic variant in a multi-cancer risk locus at chromosome 5p15.33 that explains, at least in part, the molecular mechanism through which this variant influences cancer risk.
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Increasing Thyroid Cancer Incidence and Mortality in the United States
A new analysis of thyroid cancer trends found significant increases in both incidence and mortality overall and for advanced-stage papillary thyroid cancer.
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From India, first evidence of common genetic variation associated with gallbladder cancer risk
In the first-ever large genome-wide association study (GWAS) of gallbladder cancer, researchers have identified common genetic changes associated with elevated risk of the often fatal malignancy.
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No increased risk of death among U.S. physicians who perform fluoroscopy-guided interventional procedures compared to psychiatrists
U.S. physicians who performed fluoroscopy-guided interventional procedures (FGI MDs) found no increased risk of death (total and cause-specific), compared to physicians who did not perform these types of tests (psychiatrists).
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Unexpected Findings Reveal Genetic Mosaicism as Possible Early Marker for Disease
DCEG scientists have made surprising observations that a substantial number of adults—individuals who did not have cancer at the time their DNA was scanned—have large structural chromosomal abnormalities, known as mosaicism. In addition, they found that the number of abnormalities an individual may carry appear to increase as they age. Some proportion may be related to environmental exposures, including smoking. These unexpected findings are exciting for a number of reasons; they could lead to new insights on how and why the risk of cancer increases with age, and they might eventually help identify people at higher-than-average risk of developing certain cancers.