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Linkage Newsletter - DCEG News Updates

Longer-format articles that go in-depth on DCEG research or profile investigators. These articles are distributed three times each year as the DCEG Newsletter, Linkage.

    • With Big Data Come Big Responsibilities
      , by Elise Tookmanian, Ph.D.

      Data science provides a powerful transdisciplinary approach to data stewardship and analysis that allows researchers to take full advantage of the increasing scale of epidemiological data. DCEG investigators are implementing this approach across the Division by building collaborative data platforms and software tools for large-scale epidemiological research.

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    • Making Strides Toward Precision Medicine for Individuals with Li-Fraumeni Syndrome
      , by Maura Kate Costello, M.A.

      LFS research conducted in the Clinical Genetics Branch reveals nuanced cancer incidence patterns, key distinctions within the LFS population, and areas for improvement in TP53 variant classification and clinical management.

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    • Beyond the Signature: Exposing Mutational Patterns of Cancer
      , by Justine E. Yu, Ph.D.

      Mutational signature analysis is a powerful tool for natural history and etiologic studies and could identify high-risk populations that may benefit from tailored screening, treatment, and prevention strategies. DCEG scientists seek to uncover the relationship between these unique signature patterns and the internal processes or external exposures that caused a tumor to develop.

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    • COVID-19 Research: Cancer Screening, Mosaicism and Infection, Seroprevalence Data Visualization
      , by Sharon A. Savage, M.D., and Jennifer K. Loukissas, M.P.P.

      Cancer screening in the context of the pandemic, clinical validation of SARS-CoV-2 assays, genetic mosaicism and respiratory infection risk, seroprevalence data visualization tools, and more. Learn about the latest research on SARS-COV-2 with DCEG.

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    • Director’s Update: Welcoming New Leaders to the NCI
      , by Stephen J. Chanock, M.D.

      Dr. Stephen Chanock welcomes the newest director-level scientist to NCI, Dr. Katrina Goddard, and reflects on DCEG’s participation in numerous collaborations across the NCI divisions which have yielded research innovations and foundational resources.

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    • Yei Eun Shin, New Tenure-track Investigator in Biostatistics
      , by Justine E. Yu, Ph.D.

      Yei Eun Shin was appointed tenure-track investigator in the Biostatistics Branch in Spring 2021. Dr. Shin will design complex models to study the impact of spatiotemporal exposures in epidemiological cohort studies such as physical activity and light exposures on risk of cancer and other diseases.

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    • Mentorship at DCEG: A Tradition of Excellence, ITEB
      , by Justine E. Yu, Ph.D.

      This is the second installment of the Mentorship at DCEG: A Tradition of Excellence series. Gretchen Gierach, Ph.D., M.P.H., Chief of the Integrative Tumor Epidemiology Branch, and mentees Brittny Davis Lynn, Ph.D., M.P.H., and Mustapha Abubakar, M.D., Ph.D., describe their training and mentoring experiences at DCEG.

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    • 2021 Intramural Research Awards

      DCEG Intramural Research Awards are competitive funding opportunities designed to foster creative, high-impact research by fellows and tenure-track investigators.

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    • Strategic Plan Outlines Research Priorities
      , by Jennifer K. Loukissas, M.P.P.

      The five-year strategic plan outlines the critical elements to evaluate emerging exposures, including novel biomarkers, employing cutting-edge exposure assessment for a research program that utilizes the full potential of new analytic technologies and data sources. A key focus is a research program that reflect the racial and ethnic diversity of the U.S. population.

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    • Building A Robust Community for Fellows in the COVID-19 Era
      , by Maura Kate Costello, M.A.

      Jackie Lavigne, Ph.D., Diane Wigfield, and Cara Murray of the Office of Education have supported fellows during the work-from-home order. They have bridged the distance inflicted by COVID-19 through virtual events, on-line and telephone support, providing virtual professional development workshops, and more.

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    • COVID-19 Research Across the Division: DCEG Experts Address the Pandemic
      , by Sharon A. Savage, M.D., and Jennifer K. Loukissas, M.P.P.

      Investigators have uncovered important differences in mortality patterns over the course of the pandemic, identified a novel isoform of ACE2, launched a hub to monitor seroprevalence, evaluated risks for cancer patients, and possible late effects of COVID-19, and more.

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    • Mentorship at DCEG: A Tradition of Excellence
      , by Justine E. Yu, Ph.D.

      Over the years, DCEG has trained hundreds of epidemiologists who have contributed to advancements in public health. Investing in mentorship and training has been essential to the Division’s success and longevity as a premier research program of cancer epidemiology and genetics. Past and present mentor-mentee pairs describe their training and mentoring experience at DCEG.

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    • The Training Experience at DCEG
      , by Justine E. Yu, Ph.D.

      DCEG prides itself as an optimal training environment for those interested in conducting research in cancer epidemiology by championing innovative opportunities to obtain integrated scientific and career training. 10 current fellows share their training experience in DCEG.

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    • Laboratories Move to NCI Shady Grove Campus, Unifying DCEG

      The Laboratory of Translational Genomics, the Laboratory of Genetic Susceptibility, and the Cancer Genomics Research Laboratory joined the rest of the Division staff as occupants of a new constructed state of the art laboratory and staff building at Shady Grove.

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    • Branch Profile: Biostatistics
      , by Jennifer K. Loukissas, M.P.P.

      Underpinning nearly every research study conducted by DCEG is a collaboration with investigators in the Biostatistics Branch (BB). While highly trained and experienced epidemiologists can and do design their own analytic plans and calculate statistical power and other parameters, biostatisticians in BB ensure the statistical validity and strength of all DCEG research while actively engaging in the development of novel methods and tools.

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    • Allen Wilcox Delivers 2020 Wacholder Lecture
      , by DCEG Staff

      Dr. Wilcox, Scientist Emeritus in the Epidemiology Branch, Reproductive Epidemiology Group at the National Institute of Environmental Health Sciences delivered the Sholom Wacholder Distinguished Lecture on The Cost of False-Positive Results: A Personal History.

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    • Jennifer Loud Retires after 27 Years of Service to the NCI

      Jennifer Loud, adult nurse practitioner and assistant chief in the Clinical Genetics Branch, retired after 27 years of NCI service.

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    • 2020 Fellows' Symposium Focused on Research in Underrepresented Populations
      , by DCEG Staff

      The twelfth annual DCEG Fellows’ Symposium was held virtually on July 2, 2020. The theme for this year was “Mine the Gap: Research in Underrepresented Populations,” and explored the challenges in health disparities among underrepresented populations and the role of research in closing the gap.

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    • Robert Hoover Retires Leaving a Legacy of Cancer Epidemiology Research
      , by Justine E. Yu, Ph.D.

      In June 2020, Dr. Robert Hoover, Director of the Epidemiology and Biostatistics program, retired from the Division of Cancer Epidemiology and Genetics after a remarkable 48 years of service to the National Cancer Institute.

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    • Retrospective on the Informatics Tool Challenge: Driving Innovation and Creativity at DCEG
      , by Justine E. Yu

      The Informatics Tool Challenge, launched in 2014, provides a unique, supplementary funding source for DCEG researchers seeking to create novel tools to enhance data collection, analysis, and other avenues of investigation. A sampling of tools that illustrate the growth and success of the Challenge are described.

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