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Discovering the causes of cancer and the means of prevention
 

Autoimmune Gastritis

DCEG investigators in the Infections and Immunoepidemiology Branch (IIB) have documented unprecedented increases of noncardia gastric cancer among younger generations in the U.S. Analyses of incidence trends reveal a coherent set of features that suggest autoimmune gastritis may be the underlying cause, including predominance among non-Hispanic whites, women, higher-income groups, and gastric corpus-localization. Additional efforts are underway examining large-scale medical record databases to assess magnitude of gastric cancer associations with autoimmune conditions and estimate population attributable risk. Follow-up studies are planned to evaluate potential biomarkers of risk in prospective cohorts.

For more information, contact Charles Rabkin.

Infections and Immunoepidemiology Branch - Research Areas