DCEG investigators in the Infections and Immunoepidemiology Branch (IIB) have documented unprecedented increases of noncardia gastric cancer among younger generations in the U.S. Analyses of incidence trends reveal a coherent set of features that suggest autoimmune gastritis may be the underlying cause, including predominance among non-Hispanic whites, women, higher-income groups, and gastric corpus-localization. Additional efforts are underway examining large-scale medical record databases to assess magnitude of gastric cancer associations with autoimmune conditions and estimate population attributable risk. Follow-up studies are planned to evaluate potential biomarkers of risk in prospective cohorts.
For more information, contact Charles Rabkin.