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Discovering the causes of cancer and the means of prevention

COVID-19 Related Research in DCEG

DCEG investigators are applying their expertise to accelerate our understanding of the range of outcomes in patients with COVID-19 and identify those at greatest risk of adverse outcomes. Collaboration and a multidisciplinary approach are the hallmarks of COVID-related research, often with local, state, or federal organizations, as well as international research groups all working together to advance discovery.

Research Studies

COVID-Mortality Tracker

A collaboration of epidemiologists and data scientists to monitor weekly U.S. trends in overall and cause-specific mortality since the onset of the pandemic. COVID-Mortality Tracker displays publicly-available provisional vital statistics data from the National Center for Vital Statistics at the Centers for Disease Control and Prevention (CDC). Explore the COVID-Mortality Tracker.

COVNET: Large-scale Genome-wide Association Study and Whole Genome Sequencing of COVID-19 Severity

A large genome-wide association study (GWAS) to identify common and rare germline genetic variants associated with susceptibility to severe or fatal COVID-19 disease. Learn more about COVNET.

The COVIDcode Study

A collaboration with the National Human Genome Research Institute and the National Institute of Allergy and Infectious Diseases to learn more about the genetic and immunologic contributions to the severity of disease of COVID-19. Distinct from COVNET, COVIDcode is actively enrolling study participants, including NIH Clinical Center patients and NIH staff. Learn more about COVIDcode.

The COV2Base Study

A collaboration with the National Heart, Lung, and Blood Institute to examine the effect of SARS-CoV2 infection on patients with rare diseases (e.g., Li-Fraumeni syndrome, DICER1-syndrome), quantifying the frequency and severity and looking for conditions that increase risk of severe outcomes. Additionally, this project will work to identify gene, tissue, or sociodemographic characteristics that increase risk of severe COVID outcomes that may inform future genetic modifier studies.

The COVID-19 and Cancer Linkage Study (COVCan)

In collaboration with state health departments, DCEG investigators are leading an effort to link data from several state cancer registries and COVID-19 surveillance systems. The COVID-19 and Cancer Linkage (COVCan) Study will allow investigators to assess the risk of COVID-19 hospitalization and death among cancer patients and survivors, as well as identify patient characteristics and cancer sites exhibiting the strongest associations with severe COVID-19. For more information, contact Meredith Shiels, Ph.D.