KinCohort

KinCohort is a MATLAB software package for likelihood-based analysis of kin-cohort data.

Readme text:

1. Download the zip file and unpack it in an appropriate directory.
2. In MATLAB, use the (file--> set path) menu to add the directory to the search path in which the files have been placed.
3. The main user interface programs are:
   • 'pexpsurv_kk' which produces the kin-cohort estimate of survival curves, and
   • 'bspexpsurv_kk' which produces bootstrap estimates of the survival curves.
    
4. Both of these functions have been annotated to explain the input and output arguments.

License Agreement 

Download Software:

• Download the zip file KinCohort.ZIP and unpack it in an appropriate directory.
• In MATLAB, use the (file--> set path) menu to add the directory to the search path in which the files have been placed.
• The main user interface programs are:
  • ‘pexpsurv_kk’ which produces the kin-cohort estimate of survival curves, and
  • ‘bspexpsurv_kk’ which produces bootstrap estimates of the survival curves.
• Both of these functions have been annotated to explain the input and output arguments.

Reference:

• A marginal likelihood approach for estimating penetrance from kin-cohort designs. Chatterjee N and Wacholder S. Biometrics 2001 Mar;57(1):245-52.

See also:

• The kin-cohort study for estimating penetrance. Wacholder et al. Am J Epidemiol 1998 Oct 1;148(7):623-630.
• Pseudo-likelihood estimates of the cumulative risk of an autosomal dominant disease from a kin-cohort study. Moore et al. Genet Epidemiol 2001 Feb;20(2):210-27.

Support:

Questions? Contact DCEG.