SUITOR: Selecting the Number of Mutational Signatures through Cross-Validation.
For de novo mutational signature analysis, estimating the correct number of signatures is the crucial starting point, since it influences all the downstream steps, including extraction of signature profiles, estimation of signature activities, and classification of tumors based on the estimated activities. Here we present an R package SUITOR, an unsupervised cross-validation tool to select the optimal number of signatures.
SUITOR_1.0.1.tar.gz – Unix O/S
SUITOR_1.0.1.zip – for Windows, R version >=4.0
Lee D, Wang D, Yang XR, Shi J, Landi MT, and Zhu B. SUITOR: Selecting the number of mutational signatures through cross-validation. PLoS Comput Biol 2022 Apr. doi: 10.1371/journal.pcbi.1009309.
Questions, please contact Dr. Bin Zhu.