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SUITOR: Selecting the Number of Mutational Signatures through Cross-Validation

Description

SUITOR is an R package, an unsupervised cross-validation tool to select the optimal number of signatures for mutational signature analysis.

Details

For de novo mutational signature analysis, estimating the correct number of signatures is the crucial starting point since it influences all the downstream steps, including extraction of signature profiles, estimation of signature activities, and classification of tumors based on the estimated activities. Here we present an R package SUITOR, an unsupervised cross-validation tool to select the optimal number of signatures.

SUITOR User Guide

Download

SUITOR_1.0.1.tar.gz – Unix O/S

SUITOR_1.0.1.zip – for Windows, R version >=4.0

Reference

Lee D, Wang D, Yang XR, Shi J, Landi MT, and Zhu B. SUITOR: Selecting the number of mutational signatures through cross-validation. PLoS Comput Biol 2022

Support

Questions, please contact Dr. Bin Zhu.

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