Skip to main content
Discovering the causes of cancer and the means of prevention
 

SUITOR

Description

SUITOR: Selecting the Number of Mutational Signatures through Cross-Validation.

Details

For de novo mutational signature analysis, estimating the correct number of signatures is the crucial starting point, since it influences all the downstream steps, including extraction of signature profiles, estimation of signature activities, and classification of tumors based on the estimated activities. Here we present an R package SUITOR, an unsupervised cross-validation tool to select the optimal number of signatures.

User Guide_SUITOR.pdf

Download

SUITOR_1.0.1.tar.gz – Unix O/S

SUITOR_1.0.1.zip – for Windows, R version >=4.0

Reference

Lee D, Wang D, Yang XR, Shi J, Landi MT, and Zhu B. SUITOR: Selecting the number of mutational signatures through cross-validation. PLoS Comput Biol 2022 Apr. doi: 10.1371/journal.pcbi.1009309.

Support

Questions, please contact Dr. Bin Zhu.

If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “SUITOR was originally published by the National Cancer Institute.”