Date Updated: 10/28/2014
Date Created: 05/26/2010
Short instruction file on the use of the men's colorectal cancer (CRC) absolute risk
projection SAS macro (Men_CRC_RAM),
The men's colorectal cancer absolute risk projection SAS macro, Men_CRC_RAM needs
the following information as input to estimate absolute risk of colorectal cancer:
Race =1, white
=2, african-american
=3, hispanic
=4, asian-american
T1 T1, current age ranges from: 50 to 85
T2 T2, projection age ranges from: T2>T1 and T2<=90
Sigmoid_Polyps =0, yes sigmoidoscopy and/or colonscopy last 10 years, no history of polyps
=1. no sigmoidoscopy and/or colonscopy last 10 years
=2, yes sigmoidoscopy and/or colonscopy last 10 years, yes history of polyps
=3, unk sigmoidoscopy and/or colonscopy last 10 years, unk history of polyps or
yes sigmoidoscopy and/or colonscopy last 10 years, unk history of polyps
NoIBuprofin =0, regular user of non aspirin containin NSaids, e.g. IBuprofin only or
dont know denoted on the input data as -9
=1, non user of non aspirin containin NSaids, e.g. IBuprofin only
Vigorus_Xrcis =0, 0 hrs/wk
=1, greater than 0 and less than equal 2 hrs/wk
=2, greater than 2 and less than equal 4 hrs/wk
=3, greater than 4 hrs/wk
Cig_Yrs =0, # yrs cigarette smoking = 0 or
dont know denoted on the input data as -9
=1, # yrs cigarette smoking > 0 and < 15
=2, # yrs cigarette smoking >= 15 and < 35
=3, # yrs cigarette smoking >= 35
Vegetable =0, greater equal to five servings of vegetables per day
=1, less than five servings of vegetables per day
Num_Cigs =0, # cigarettes smokes = 0 or
dont know denoted on the input data as -9
=1, # cigarettes smokes >= 1 and < 11
=2, # cigarettes smokes >= 11 and <= 20
=3, # cigarettes smokes >= 21
BMI_Trnd =0, BMI <= 24.9
=1, BMI > 24.9 and BMI <= 29.9
=2, BMI > 29.9
No_NSaids =0, regular user of asprin containing NSaids or
dont know denoted on the input data as -9
=1, non user of asprin containing NSaids
Fam_Hist_CRC =0, 0 relative with CRC (CRC=Colorectal Cancer) or
dont know if any relatives with CRC denoted by -9
=1, 1 relative with CRC or
have relative with CRC, dont know how many denoted by -8
=2, 2 or more relatives with CRC
!!!!!!!!!!!! Warning Warning Warning Warning Warning Warning !!!!!!!!!!!!
!!!!!!!!!!!! Warning about an inadmissible error condition !!!!!!!!!!!!
Inadmissable condition of NoIBuprofin=0 and No_NSAIDS=1
i.e. individual uses IBuprofin but does not use NSaids.
This is contradictory since IBuprofin is a NSaid drug
projected absolute risk for records with this contradition will be missing
!!!!!!!!!!!! Warning about an inadmissible error condition !!!!!!!!!!!!
!!!!!!!!!!!! Warning Warning Warning Warning Warning Warning !!!!!!!!!!!!
A short SAS sample program, Men_CRC_Template.sas, which reads a covariate input dataset, Men_CRC_raw.in,
are included to more clearly demonstrate the use of the SAS macro Men_CRC_RAM. User's can run
the program Men_CRC_Template.sas for instructional and clarification purposes
Ref: "Colorectal Cancer Risk Prediction Tool for White Men and Women Without Known
Susceptibility". A Freedman et al. JCO 27:686-693 2008.
References:
- Freedman AN, Slattery ML, Ballard-Barbash R, Willis G, Cann B, Pee D, Gail MH, Pfeiffer RM. A colorectal cancer risk prediction tool for white men and women without known susceptibility. J Clin Oncol 2009 Feb 10;27(5):686-93.
- Park Y, Freedman AN, Gail MH, Pee D, Hollenbeck A, Schatzkin A, Pfeiffer RM. Validation of a colorectal cancer risk prediction model among whites 50 years old and over. J Clin Oncol 2009 Feb 10;27(5):694-8.