Linkage Newsletter - News Updates
Linkage is the newsletter from the NCI Division of Cancer Epidemiology and Genetics (DCEG), highlighting the latest research from the DCEG, longer-format articles that go in-depth on a specific topic, staff and fellowship news, the latest job openings, Q&As with former fellows, and the Inclusivity Minute, written by DCEG fellows. Issues are delivered to your inbox at the beginning of March, July, and November.
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Lisa Mirabello: Using Genetic Data to Understand Osteosarcoma Etiology and HPV Carcinogenicity
Profile of Lisa Mirabello in the Clinical Genetics Branch. Dr. Mirabello uses genetic data to understand osteosarcoma etiology and HPV carcinogenicity.
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Exploring the Relationship Between Mammographic Breast Density and Breast Cancer
Dr. Gretchen Gierach and colleagues employ a range of technologies and approaches to study mammographic breast density and its relationship to breast cancer risk.
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Applying 3-Dimensional Printing for Radiation Exposure Assessment
Researchers are using 3D printing to create tools for health physicists to improve their estimates of radiation dose for epidemiological studies.
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Unexpected Findings Reveal Genetic Mosaicism as Possible Early Marker for Disease
DCEG scientists have made surprising observations that a substantial number of adults—individuals who did not have cancer at the time their DNA was scanned—have large structural chromosomal abnormalities, known as mosaicism. In addition, they found that the number of abnormalities an individual may carry appear to increase as they age. Some proportion may be related to environmental exposures, including smoking. These unexpected findings are exciting for a number of reasons; they could lead to new insights on how and why the risk of cancer increases with age, and they might eventually help identify people at higher-than-average risk of developing certain cancers.
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Using Geographic Information Systems to Improve Exposure Assessment in Epidemiological Studies of Cancer
Description of epidemiologic studies that are using geographic information system (GIS) technology, recently-available data resources, and novel analytic methods to home in on environmental causes of cancer.
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Shedding Light on the Etiology of Male Breast Cancer
Drs. Louise Britton and Michael Cook investigate the etiology of male breast cancer
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Clinical Genetics Branch Discovery: RTEL1 Founder Mutation Among Ashkenazi Jews
Clinical Genetics Branch Discovery: RTEL1 Founder Mutation Among Ashkenazi Jews - reported in the Spring 2016 issue of Linkage newsletter, published by the NCI Division of Cancer epidemiology & Genetics
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Exploring the Causes and Course of Lung Cancer in Northern Italy
DCEG genetic epidemiologists and collaborators from the University of Milan in Italy have been working to uncover critical steps that lead to lung cancer development and identify opportunities to interrupt that progression.
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DCEG Gains Two New Earl Stadtman Investigators
Lisa Mirabello, Ph.D., M.S., and Steven C. Moore, Ph.D., M.P.H., have been selected as NIH Earl Stadtman Investigators. Named after a noted biochemist at the National Heart, Lung, and Blood Institute, the Stadtman program is a trans-NIH recruitment initiative designed to attract the most talented early career scientists to NIH.
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Translational Research Fulfilling the Promise of Genome-Wide Association Studies
Newsletter article discusses examples of the use of genome-wide association studies in translational cancer research
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Lindsay Morton: Making the Most of Consortia
In almost all of her research, Lindsay M. Morton, Ph.D., has used either formal consortia or extensive networks of scientific collaborators in the search for clues to the causes of cancer. A tenure-track investigator in DCEG’s Radiation Epidemiology Branch (REB), Dr. Morton has focused her research on areas of cancer epidemiology that require large numbers of subjects: rare outcomes, histologic subtypes, and gene-environment interactions. July 2013 Linkage Newsletter
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Tenure-Track Investigators Develop New Methods for Genetic Analyses
Tenure-Track Investigators Develop New Methods for Genetic Analyses, March 2013 Linkage
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Diesel Methodology Papers Earn 2012 Thomas Bedford Memorial Prize
The British Occupational Hygiene Society awarded the 2012 Thomas Bedford Memorial Prize to four papers describing the methods used to estimate occupational exposures in the DCEG Diesel Exhaust in Miners Study.
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Understanding the Risks of Medical Radiation
DCEG investigators in the Radiation Epidemiology Branch led new studies that shed further light on cancer risks related to low-dose diagnostic and screening procedures and to high-dose radiation therapy. March 2013 Linkage newsletter
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Margaret Tucker Appointed as DCEG Acting Director
Margaret Tucker Appointed as DCEG Acting Director, December 2012 Linkage Newsletter
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Joseph Fraumeni's Contributions to the Scientific Literature
Joseph Fraumeni's Contributions to the Scientific Literature - December 2012 Linkage Newsletter
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Reflections on the Past and Future of Epidemiology
DCEG was privileged to hold a panel discussion titled Cancer Epidemiology over the Last Half-century and Thoughts on the Future, featuring Dr. Joseph F. Fraumeni, Jr., and Dr. David Schottenfeld, University of Michigan, co-editors of multiple editions of the indispensable textbook Cancer Epidemiology and Prevention. Dr. Robert N. Hoover, Director of DCEG’s Epidemiology and Biostatistics Program, moderated the discussion and posed questions on the major influences that affected the careers of Drs. Fraumeni and Schottenfeld, the key contributors and seminal discoveries in the field of cancer epidemiology, and advice for young epidemiologists. December 2012 Linkage Newsletter
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The Public Health Impact of DCEG Research
The Public Health Impact of DCEG Research - December 2012 Linkage newsletter
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From Early Research Themes to the Present
For a majority of scientific themes under study across the Division, Dr. Joseph F. Fraumeni, Jr. conducted seminal work showing the promise of that particular line of research for yielding clues to cancer etiology and prevention. November 2012 Linkage newsletter