Research Highlights - News Updates
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Never Too Late to Start: Benefits of Exercise Continue Throughout Adulthood
It is never too late to benefit from exercise, study finds; physical activity throughout adulthood decreases risk of all-cause mortality, cardiovascular disease, and cancer mortality.
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Obesity-related Cancer Trends Among Young Adult U.S. Population
Study finds increased incidence of obesity-related cancers in children and young adults in U.S.-based cancer registries.
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Controlling Cervical Cancer: DCEG’s Ongoing Commitment to Improving Women’s Health
Scientists in DCEG are among the leaders of a growing global effort to greatly reduce deaths from cervical cancer
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Patterns of Cause-Specific Mortality in Survivors of Retinoblastoma, 1914-2016
Mortality patterns among survivors of retinoblastoma differ by hereditary status, cause of death, calendar year of diagnosis, treatment, and time since diagnosis. Study conducted by NCI, Memorial Sloan Kettering Cancer Center, and University of Massachusetts Medical Center.
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Cancer Risk in Non-Proband DICER1-Variant Carriers
A new report establishes the first quantitative, site-specific risk for benign and malignant tumors in over one hundred individuals with a germline DICER1 pathogenic variant.
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CHEK2 Identified as Intermediate-risk Driver of Testicular Germ Cell Tumor Susceptibility
CHEK2 germline pathogenic variants are associated with a four-to-six times elevated risk for Testicular Germ Cell Tumors (TGCT), and an average age at presentation six years earlier than carriers of wild-type alleles.
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Drug Overdose Deaths a National Problem, not Limited to Poor, Rural Counties
Researchers in the NCI Division of Cancer Epidemiology and Genetics and collaborators at the National Institutes of Health conducted a formal analysis of overall death rates and death rates from drug poisoning among 25-64-year-olds in the United States. They compared rates across race/ethnicity, socioeconomic status, rurality and geography to determine whether increases in these deaths are limited to poor, rural, white communities in regions with high unemployment.
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AI Approach Outperformed Human Experts in Identifying Cervical Precancer
A research team led by investigators from NIH and Global Good has developed a computer algorithm that can analyze digital images of a woman’s cervix and accurately identify precancerous changes that require medical attention.
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BRCA Exchange Aggregates Data on Thousands of BRCA1 and BRCA2 Variants
BRCA Exchange is a global resource with data and expert classification on thousands of inherited variants in the BRCA1 and BRCA2 genes that will improve cancer prevention, screening, and intervention for high-risk patients.
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HPV Screening History Important for Management of New, Abnormal Results
HPV screening history of multiple negative HPV and cytology cotests important for management of current results in cervical cancer screening programs. The data come from over a million women aged 30 and older in Kaiser Permanente Northern California.
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Study finds elevated risk of certain rare blood cancers after chemotherapy for most solid tumors
Findings from a new study by researchers at the National Cancer Institute (NCI) show that patients treated with chemotherapy for most solid tumors experienced an increased risk of myelodysplastic syndrome/acute myeloid leukemia (tMDS/AML).
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Association between Benzene Exposure and Leukemia Risk Refined
In a follow-up to a long-term study of Chinese workers exposed to benzene, DCEG researchers observed increased risks for the combined grouping of acute myeloid leukemia and myelodysplastic syndromes with increasing cumulative exposure for certain windows and ages of exposure.
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Pediatric Considerations Before, During, and After Radiological/Nuclear Emergencies
A new report, “Pediatric Considerations Before, During, and After Radiological/Nuclear Emergencies,” published in the November 2018 issue of Pediatrics, summarizes appropriate management of the pediatric population in the event of a radiologic disaster.
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Trends in Pediatric Central Nervous System Tumor Incidence in U.S., 1998-2013
Brain and other central nervous system cancers are the leading cause of pediatric cancer mortality in the US. A new study describes overall rates, which have remained stable, and modest changes in the incidence rates of certain subtypes.
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No Safe Level of Smoking: Mortality Risks Described for Occasional Smokers and Smokers Who Cut Back
DCEG investigators examined the effect of how non-daily smoking and changes in the number of cigarettes smoked per day on mortality.
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Understanding the Etiology of Gynecologic Cancers: Profile of Tenure-Track Investigator Britton Trabert
Tenure-track investigator Britton Trabert, Ph.D., M.S., studies the epidemiology of ovarian cancer and the hormonal etiology of gynecologic cancers.
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Metabolomics: The Growing Potential of an Emerging Field
DCEG scientists have been evaluating the performance of metabolomics assays and applying them to studies of cancer etiology.
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Occupational Exposure to Low-dose Ionizing Radiation Increases Risk of Cataract
Investigators in the Radiation Epidemiology Branch have identified a significant exposure-response between low-dose cumulative occupational radiation exposure to the eye lens and risk of cataracts.
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For HPV-Positive Women, Test Can Guide Cervical Cancer Screening Follow-Up
A new test can help to improve the clinical management of women who screen positive for human papillomavirus (HPV) infection in routine cervical cancer screening, an NCI-led study has shown.
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Pediatric Mortality Decreases in U.S., but Rates Still Higher than Canada and U.K.
All-cause mortality rates in the U.S. have decreased in most age and racial/ethnic groups, but rates remain higher and are improving more slowly than other high-income nations.