Biliary Tract Cancers
Bile Duct, Gallbladder, and Ampulla of Vater
To better understand the etiology of rare cancers that form in the biliary tract (bile duct, gallbladder, ampulla of Vater), DCEG researchers are conducting studies to examine the molecular and epidemiologic characteristics of cancer at different sites in the biliary tract and identify potential molecular subtypes. Tumor and other biologic samples are compiled from various efforts in China and Chile, where incidence of these cancers is higher than in the United States.
|Activity||Shanghai BTC Study||BiTCaPP||Chile BiLS|
As more samples and accompanying exposure information are collected, investigators are able to study increasingly rare subtypes with cutting-edge techniques to determine the epidemiologic and molecular contributors to the development of biliary tract cancers. A better understanding of the molecular differences across these malignancies can lead to more precise diagnosis and effective treatment, as well as provide clues as to etiology. Studies include:
The Chile Biliary Longitudinal Study aims to investigate the risk factors for gallbladder dysplasia and cancer, by studying a cohort of women with gallstones in Chile. Its secondary aim is to explore whether and how associations with risk factors, e.g., BMI, diabetes, and metabolic syndrome, are mediated through inflammation.
The Biliary Tract Cancer Pooling Project (BiTCaPP) was created to help evaluate the contribution of risk factors throughout the biliary tract, providing important insight into the etiologic heterogeneity that exists at various locations within the biliary tract.
The Shanghai Biliary Tract Case-Control Study has the primary goal of investigating biliary tract cancers, including investigation of biologic markers and epidemiologic risk factors for gallbladder, extrahepatic bile duct, and ampulla of Vater cancers.
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