Interdisciplinary Case-Control Study of Bladder Cancer in Spain

DCEG conducted a large interdisciplinary case-control study of bladder cancer (1,200 cases and 1,200 controls) in 18 hospitals from five different regions in Spain. This effort was a collaboration between investigators in DCEG's Occupational and Environmental Epidemiology Branch (OEEB) and investigators from the Centre for Research in Environmental Epidemiology (CREAL) in Barcelona and Centro Nacional de Investigaciones Oncologicas (CNIO) in Madrid, Spain. A computer-aided personal interview (CAPI) system was developed to collect detailed information on tobacco use (black or blond), occupational and environmental exposures, medical history and drug use, family history and diet. Blood collection and processing allowed for testing for genetic susceptibility markers such as CYP1A1, NAT1, NAT2, GSTM1, DNA repair capacity, and mutagen sensitivity.

For more information, contact Dr. Nathaniel Rothman.

Occupational and Environmental Epidemiology Branch - Research Areas