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Discovering the causes of cancer and the means of prevention

Confluence Project

The Confluence Project will develop a large research resource by 2020 to uncover breast cancer genetics through genome-wide association studies (GWAS). The resource will include at least 300,000 breast cancer cases and 300,000 controls of different races/ethnicities. This will be accomplished by the confluence of existing GWAS and new genome-wide genotyping data to be generated through this project.

Broad scientific aims that can be addressed through this resource include:

  1. Advancing knowledge of breast cancer etiology through the discovery of novel susceptibility loci and modelling of the underlying polygenic architecture, informed by functional genomic data.
  2. Improving personalized risk assessment for breast cancer, overall and by clinically relevant subtypes, by integrating polygenic information into risk models for risk-based prevention and screening. 
  3. Improving breast cancer prognostication for recurrence, mortality, response to treatment and second cancers through the identification of loci related to clinical outcomes. 

Eligibility criteria

To be eligible to participate, studies with cases of in situ or invasive breast cancer (females or males) must have:

  • Genome-wide genotyping data or germline DNA for genotyping, i.e.:
    • existing genome-wide genotyping data, or
    • germline DNA available for new genotyping, or
    • blood/buccal samples for germline DNA isolation and genotyping.
  • Basic phenotype data (e.g. age at diagnosis, gender, family history of breast cancer)
  • Appropriate ethics approval for genetic studies and data sharing

Please complete the study inventory if you are interested in participating in the Confluence Project. We will perform an initial evaluation of interested studies that respond by September 30, 2018, and will consider additional studies until December 14, 2018. This inventory is for planning purposes only and implies no commitment to participate.

The Confluence Project is supported by NCI Intramural Research funds.

Integrative Tumor Epidemiology Branch- Research Areas