The Confluence project will develop a large research resource to uncover breast cancer genetics through genome-wide association studies (GWAS). The resource will include at least 300,000 breast cancer cases and 300,000 controls of different races/ethnicities. This will be accomplished by the confluence of existing GWAS and new genome-wide genotyping data to be generated through this project.
Broad scientific aims that can be addressed through this resource include:
- To discover susceptibility loci and advance knowledge of etiology of breast cancer overall and by subtypes.
- To develop polygenic risk scores and integrate them with known risk factors for personalized risk assessment for breast cancer overall and by subtypes.
- To discover loci for breast cancer prognosis, long-term survival, response to treatment, and second breast cancer.
For more information, please see the Confluence Data Platform.
Please contact the project manager, Thomas Ahearn, at ConfluenceProject@nih.gov
Confluence is supported by NCI Intramural Research funds.