DCEG researchers conduct studies on breast cancer, a cancer that usually forms in the breast ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). Breast cancer occurs in both men and women, although male breast cancer is rare. Selected studies include:
A study of breast cancer among Asian populations, including mainland China, Hong Kong, and Malaysia, with the aim of identifying distinct molecular alterations in tumors and adjacent normal tissues, and examining the associations of these molecular changes with risk factors (genetic and environmental), breast tissue composition and density, and breast cancer subtypes.
A population-based case-control study of breast cancer in Poland that combines state-of-the art techniques of exposure assessment and collection of biological specimens
A follow-up study of women who were participants in the Breast Cancer Detection Demonstration Project
Large-scale molecular pathology studies to understand how genetic and environmental risk factors are related to breast cancer tumor features and clinical progression.
A study to evaluate the use of several new, promising breast cancer screening techniques in women at high genetic risk of breast cancer
A study that aims to characterize the radiologic, histologic, and molecular features of dense breast tissue
A study established as part of NCI's Biological Markers Project to identify serum markers for breast cancer
The Confluence Project will develop a large research resource by 2020 to uncover breast cancer genetics through genome-wide association studies (GWAS). The resource will include at least 300,000 breast cancer cases and 300,000 controls of different races/ethnicities. This will be accomplished by the confluence of existing GWAS and new genome-wide genotyping data to generated through this project.
The Ghana Breast Health Study is a multidisciplinary case-control study of breast cancer in Ghana, West Africa.
Molecular epidemiologic study of terminal duct lobular units of the normal breast, conducted in collaboration with the Susan G. Komen® Tissue Bank
A study using ultrasound tomography to define the time course of volumetric breast density changes among women receiving tamoxifen treatment