Breast Cancer Research in DCEG

DCEG researchers conduct studies on breast cancer, a cancer that usually forms in the breast ducts and lobules. Breast cancer occurs in both men and women, although male breast cancer is rare. Research spans studies of environmental, lifestyle, reproductive, genetic, and other factors that may influence risk as well as studies of the microenvironment and tissues. Selected studies include:

Research News

Activity, Metabolites, and Breast Cancer
Affected metabolites include glucose regulation, amino acid, and fatty acid metabolism
Review Confirms Etiologic Heterogeneity by Breast Cancer Subtype
Dr. Amber Hurson led the largest review on risk factors for breast cancer subtypes by race and ethnicity.

DCEG Studies of Breast Cancer

Breast Cancer Among Asian Women
Studies in several Asian populations to identify molecular alterations associated with risk factors.
Breast Cancer Detection Demonstration Project Follow-up Study
A follow-up study of women who were participants in the Breast Cancer Detection Demonstration Project
Breast Cancer Tumor Characterization Studies
Genetic and environmental risk factors, breast cancer tumor features and clinical progression.
Breast Density Research in DCEG
Review DCEG studies examining breast density as it relates to risk for breast cancer
Breast Radiology Evaluation and Study of Tissues (BREAST) Stamp Project
A study that aims to characterize the radiologic, histologic, and molecular features of dense breast tissue
Columbia, Missouri Serum Bank Follow-up Study
A study to identify serum markers for breast cancer.
Confluence Project
A large research resource to uncover breast cancer genetics through genome-wide association studies.
Ghana Breast Health Study
A multidisciplinary case-control study in West Africa
Hong Kong Breast Cancer Genomics Study
The study aims to characterize genomic and molecular profiles of tumors and adjacent normal tissue collected from Chinese breast cancer patients.
Kaiser Permanente Breast Cancer Survivors Cohort
A transdisciplinary resource to study second cancers and cardiovascular disease.
Kenya Breast Cancer Study
The study utilizes molecular and genomic approaches to study breast tumors and tumor microenvironment among African women.
Outdoor Air Pollution and Terminal Duct Lobular Involution of the Normal Breast
Study on the association between exposure to fine particulate matter and terminal duct lobular involution of the normal breast.
Polish Breast Cancer Case-Control Study
A population-based case-control study of breast cancer in Poland that combines state-of-the art techniques of exposure assessment and collection of biological specimens
Ultrasound Study of the Effects of Tamoxifen on Breast Tissue
Using ultrasound to measure changes in volumetric breast density.
TDLU of the Normal Breast
Molecular epidemiologic study conducted in collaboration with the Susan G. Komen® Tissue Bank.

Risk Prediction Tools for Breast Cancer

Breast Cancer Risk Assessment Tool 2.0 R Package
BCRA is an R package that projects absolute risk of invasive breast cancer according to NCI’s Breast Cancer Risk Assessment Tool (BCRAT).
Breast Cancer Absolute Risk Model
Explanation of absolute risk modeling and how it was used to develop the NCI Risk Assessment tools (breast, colorectal and melanoma)