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Breast Cancer

DCEG researchers conduct studies on breast cancer, a cancer that usually forms in the breast ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). Breast cancer occurs in both men and women, although male breast cancer is rare. Selected studies include:

Breast Cancer Among Asian Women
Study of breast cancer study among Asian women, to identify molecular alterations in tumors and examine associations of molecular changes with risk factors.

Breast Cancer Case-Control Study in Poland
A population-based case-control study of breast cancer in Poland that combines state-of-the-art techniques of exposure assessment and collection of biological specimens.

Breast Cancer Detection Demonstration Project Follow-up Study
A follow-up study of women who were participants in the Breast Cancer Detection Demonstration Project.

Breast Cancer Risk Assessment Tool 2.0 R Package
BCRA is an R package that projects absolute risk of invasive breast cancer according to NCI’s Breast Cancer Risk Assessment Tool (BCRAT) algorithm for specified race/ethnic groups and age intervals.

Breast Cancer Tumor Characterization Studies
Large-scale molecular pathology studies to understand how genetic and environmental risk factors are related to breast cancer tumor features and clinical progression.

Breast Radiology Evaluation and Study of Tissues (BREAST) Stamp Project
The BREAST study aims to characterize the radiologic, histologic, and molecular features of dense breast tissue.

Columbia, Missouri Serum Bank Follow-up Study
A study established as part of the NCI Biological Markers Project to identify serum markers for breast cancer.

Confluence Project
The Confluence Project will develop a large research resource by 2020 to uncover breast cancer genetics through genome-wide association studies (GWAS). The resource will include at least 300,000 breast cancer cases and 300,000 controls of different races/ethnicities. This will be accomplished by the confluence of existing GWAS and new genome-wide genotyping data generated through this project.

Ghana Breast Health Study
The Ghana Breast Health Study is a multidisciplinary case-control study of breast cancer in Ghana, West Africa.

Hong Kong Breast Cancer Genomics Study
The Hong Kong Breast Cancer Genomics Study aims to characterize the genomic and molecular profiles of breast cancer tumors and adjacent normal tissue collected from Chinese breast cancer patients in Hong Kong.

Kaiser Permanente Breast Cancer Survivor Cohort
The DCEG Kaiser Permanente Breast Cancer Survivors Cohort was initiated as a transdisciplinary resource to investigate the risk of contralateral breast cancer and cardiovascular disease.

Outdoor Air Pollution and Terminal Duct Lobular Involution of the Normal Breast
A study investigating the association between exposure to fine particulate matter (PM 2.5) and terminal duct lobular involution (TDLU) of the normal breast.

Kenya Breast Cancer Study
The Kenya Breast Cancer Study utilizes molecular and genomic approaches to study breast tumors and tumor microenvironment, among African women. This study aims to improve understanding of breast cancer risk factors and corresponding clinical outcomes in this population.

Risk Factor Heterogeneity in Breast Cancer
The Risk Factor Heterogeneity in Breast Cancer Study aims to investigate the complex relationship between breast cancer risk factors, like mammographic density and terminal ductal lobular units (TDLU) involution, and clinical features, like breast cancer intrinsic and immune subtypes and outcomes.

Terminal Duct Lobular Unit Involution of the Normal Breast
Molecular epidemiologic study of terminal duct lobular units of the normal breast, conducted in collaboration with the Susan G. Komen® Tissue Bank.

Ultrasound Study of the Effects of Tamoxifen on Breast Tissue
A study using ultrasound tomography to define the time course of volumetric breast density changes among women receiving tamoxifen treatment.